March 2017

Bone marrow niches and HSC fates

Haematopoietic stem cells (HSCs) are multipotent, self-renewing progenitors that generate all mature blood cells.

March 2016

The immunology and neurobiology of multiple sclerosis

Multiple sclerosis (MS) is a neuroinflammatory condition that affects the central nervous system and presents with various neurological and cognitive symptoms.

February 2016

Innate lymphoid cells

Innate lymphoid cells (ILCs) are a recently described family of lymphoid effector cells that have important roles in immune defence and tissue remodelling.

January 2013

The immune response to HIV

A global research effort over the past three decades has discovered more about HIV than perhaps any other pathogen.

July 2011

Dendritic cells: controllers of adaptive immunity

Dendritic cells (DCs) are a heterogenous population of antigen-presenting cells that have crucial roles in promoting both pro- and anti-inflammatory immune responses.

December 2010

NK cells: receptors and functions

Natural killer (NK) cells are lymphocytes of the innate immune system that survey the body for stressed and abnormal cells.

September 2010

T cells: the usual subsets

Each individual T cell has a unique personality that is shaped by the environmental factors it encounters during its life history.

July 2010

Myeloid-derived suppressor cells

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells that are defined by their myeloid origin, immature state and ability to potently suppress T cell responses.

March 2010

Proximal tyrosine kinases that initiate T cell activation

T cells are central to a successful immune response and their activation is mediated through the engagement of the T cell receptor (TCR) by peptide-bound MHC molecules expressed by antigen-presenting cells.

January 2010

Regulatory T cells

Regulatory T cells are vital for keeping the immune system in check, helping to avoid immune-mediated pathology and unrestricted expansion of effector T cell populations.

May 2009

Antigen processing and presentation

The process by which antigen-presenting cells digest proteins from inside or outside the cell and display the resulting antigenic peptide fragments on cell surface MHC molecules for recognition by T cells is central to the body's ability to detect signs of infection or abnormal cell growth.

February 2009

CD4 + T–cell diversity

After contact with antigen–presenting cells, naive CD4+ T cells begin to differentiate towards one of several fates, which has traditionally been viewed as a dichotomy between T helper 1 (TH1) and TH2 cells.

April 2008

Innate immunity: sensing and signalling

The innate immune system is the first line of defence against invading pathogens.

June 2007

Haematopoietic stem cells, niches and differentiation pathways

Haematopoietic stem cells (HSCs) are characterized by extensive self-renewal capacity and the ability to differentiate into multiple cell lineages of the immune system.

March 2007

PI3K signalling in immune cells

Phosphoinositide 3-kinase (PI3K) has important functions in the immune system impaired PI3K signalling can lead to immunodeficiency, whereas unrestrained PI3K signalling contributes to autoimmunity and leukaemia.

July 2004

Toll-like receptor signalling

Toll-like receptors (TLRs) recognize microbial products during infection and initiate signalling pathways that culminate in the increased expression of immune and inflammatory genes.