News & Comment

Matrix component biglycan promotes CXCL13 expression to drive B cell-mediated renal inflammation.

Pre-existing antibodies specific for seasonal influenza virus promote severe disease during pandemics.

These authors put forward their view that the information obtained from experimental human malaria infections justifies the minimal potential risks in well-designed trials and will be essential to the development of an effective malaria vaccine.

Neighbouring intestinal epithelial cells communicate to enhance antibacterial responses.

CD4⁺T cells mediate the effects of oncogene inactivation on tumour growth and survival.

Hypersensitive site 2 (HS2) is essential for GATA3-mediated epigenetic modifications at theIl4locus.

pDCs are an early, transient source of type I IFNs during skin injury and viral infection.

Regulatory T cell-mediated suppression of γδ T cells prevents spontaneous colitis.

T cell help is the limiting factor for high-affinity B cell selection in germinal centres.

The chemokine receptor CX₃CR1 promotes effector T cell survival in allergic lungs.

ER stress and atherogenic lipids trigger macrophage apoptosis in atherosclerotic lesions.

Microglial cells derive from primitive haematopoietic progenitors.

This Science and Society article proposes that it is time to re-assess whether induced pluripotency will ever provide a fully autologous source of tissues for transplantation without the need for immune modulation.

Fully differentiated monocyte-derived dendritic cells mobilize to lymph nodes in response to lipopolysaccharide.