Abstract
The origins of the adaptive immune system and the basis for its unique association with vertebrate species have been a source of considerable speculation. In light of recent advances in our understanding of the developmental and functional links between the induced regulatory T cell and T helper 17 cell lineages, and their specialized relationship to the gut, we speculate that the co-evolution of these adaptive immune pathways might have given primitive vertebrates a means to benefit from the diversification of their commensal microbiota.
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Acknowledgements
This work was supported by grants AI35783, AI57956 and DK71176 from the United States National Institutes of Health and by the University of Alabama at Birmingham Mucosal HIV and Immunobiology Center. We thank members of our laboratory for helpful comments and offer our apologies to colleagues whose work could not be adequately discussed or cited owing to space limitations.
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Weaver, C., Hatton, R. Interplay between the TH17 and TReg cell lineages: a (co-)evolutionary perspective. Nat Rev Immunol 9, 883–889 (2009). https://doi.org/10.1038/nri2660
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DOI: https://doi.org/10.1038/nri2660
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