Articles in 2016

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  • B cells may protect against pre-term labour by responding to IL-33.

    • Yvonne Bordon
    Research Highlight
  • Expression of CX3CR1 defines a new memory T cell subset that surveys peripheral tissues.

    • Lucy Bird
    Research Highlight
  • In this Review, the authors summarize recent findings that illustrate the emerging roles of CCCH zinc finger proteins, which are involved in the regulation of multiple steps of RNA metabolism, in the regulation of immune responses including cytokine production, immune cell activation and immune homeostasis.

    • Mingui Fu
    • Perry J. Blackshear
    Review Article
  • Pollutants activate the aryl hydrocarbon receptor to upregulate type 2 cytokines and neurotrophic factors that drive atopic dermatitis.

    • Yvonne Bordon
    Research Highlight
  • Thymic stromal lymphopoietin increases the killing of methicillin-resistantStaphylococcus aureusin a neutrophil- and complement-dependent manner.

    • Elisabeth Kugelberg
    Research Highlight
  • The functional behaviour of haematopoietic stem cells is determined in a cell-autonomous manner by clone-specific epigenetic modifications.

    • Kirsty Minton
    Research Highlight
  • Two studies have characterized a distinct molecular signature of intratumoral CD4+regulatory T cells from various tumours that correlates with cancer prognosis.

    • Lydia Shipman
    Research Highlight
  • This Review discusses the contribution of different cytokine networks to inflammation in the central nervous system (CNS). In neuroinflammatory diseases such as multiple sclerosis, CNS-invading leukocytes produce many of the cytokines that are associated with disease. By contrast, in Alzheimer disease and other neurodegenerative diseases, tissue-resident cells are the main source of pathological cytokines.

    • Burkhard Becher
    • Sabine Spath
    • Joan Goverman
    Review Article
  • This Review provides a comprehensive overview of the influences on human immune system variation. Systems immunology analyses have revealed that variations between individuals are mainly due to non-heritable influences such as age, sex, microbiota and the environment.

    • Petter Brodin
    • Mark M. Davis
    Review Article
  • Dendritic cells (DCs) shape tolerogenic and pro-inflammatory immune responses by presenting antigens to T cells; their ability to localize in peripheral tissues and secondary lymphoid organs is crucial for these functions. This Review describes the different migratory pathways employed by subsets of DCs from distinct tissue sites, detailing their mechanistic basis and importance for maintaining health.

    • Tim Worbs
    • Swantje I. Hammerschmidt
    • Reinhold Förster
    Review Article
  • This Review provides a comprehensive overview of the early airway immune responses to infections. The authors discuss the stepwise engagement of distinct tiers of effector functions and how early airway immune responses are influenced by factors such as the environment, obesity and ageing.

    • Akiko Iwasaki
    • Ellen F. Foxman
    • Ryan D. Molony
    Review Article
  • Macrophages expressing PPARγ support skeletal muscle regeneration by inducing secretion of the myoblast growth factor GDF3.

    • Lucy Bird
    Research Highlight
  • A cell-intrinsic checkpoint restricts type 2 cytokine production by ILC2s and TH2 cells at sites of tissue damage.

    • Olive Leavy
    Research Highlight
  • Type I interferons induced by chronic viral infections suppress the induction of early neutralizing antibody responses.

    • Elisabeth Kugelberg
    Research Highlight
  • Multinuclear granuloma macrophages arise through a distinct differentiation pathway mediated by chronic TLR2 signalling, rather than by cell fusion.

    • Kirsty Minton
    Research Highlight