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Several mechanisms exist to prevent immune-mediated rejection of the allogeneic fetus. Here, Adrian Erlebacher provides an in-depth review of recent advances in our understanding of the mechanisms that control the responses of maternal T cells to antigens expressed by the conceptus.
Recent interest in identifying interferon-stimulated genes that have activity against a wide range of viruses has advanced our understanding of the IFIT and IFITM families and shown the many mechanisms by which host factors can restrict viral replication.
Thrombosis is the most frequent cause of mortality worldwide. In this Review, the authors propose that thrombosis might also have a conserved physiological role in immune defence via a process termed immunothrombosis. However, if uncontrolled, immunothrombosis facilitates pathological clot formation.
In this Viewpoint article, five leading immunologists discuss the processes involved in the resolution of inflammation. Could drugs that promote pro-resolution pathways be more effective than drugs that block pro-inflammatory mediators in treating certain chronic inflammatory diseases? The contributors debate this and other key issues in the field.