Research Highlights

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  • A new study explores the links between diet and colorectal cancer risk by showing that changes to the intestinal microbiome in mice fed a high-fat diet result in attenuated MHC class II expression by intestinal stem cells and hence impaired immune surveillance of tumour initiation.

    • Kirsty Minton
    Research Highlight
  • A new study describes the extensive transcriptional remodelling that occurs in neutrophils during inflammation, detailing the transcription factors that control neutrophil maturation and effector functions.

    • Lucy Bird
    Research Highlight
  • The type 2 cytokine TSLP acts on T cells to promote sebum secretion and uses up lipids in this process, leading to loss of white adipose tissue.

    • Yvonne Bordon
    Research Highlight
  • Intestinal IgA responses to commensal fungi are mutualistic, selecting for fungi that are less pathogenic and more fit.

    • Yvonne Bordon
    Research Highlight
  • A new study in Cell provides a single-cell map of the epigenetic and transcriptomic landscape in response to influenza vaccination, revealing persistent epigenomic remodelling in myeloid cells and the antiviral effects of adjuvant.

    • Lucy Bird
    Research Highlight
  • A new study in Cell provides a cellular atlas of the oral mucosa, revealing complex stromal–immune cell interactions that support inflammatory responsiveness and neutrophil recruitment.

    • Lucy Bird
    Research Highlight
  • This study reports serum metabolome profiling of children naturally infected with Plasmodium falciparum in Burkina Faso, West Africa, revealing major changes in endogenous steroid levels with effects on adaptive immunity.

    • Kirsty Minton
    Research Highlight
  • A new study in Nature shows that sensory neurons communicate with dermal macrophages after sunburn-like skin damage to favour healing over inflammation.

    • Lucy Bird
    Research Highlight
  • Sussan Nourshargh and colleagues outline a mechanism for the reverse transendothelial migration of neutrophils that they observe occurs more frequently in aged mice than in young mice.

    • Kirsty Minton
    Research Highlight
  • Mitohormesis is observed in macrophages exposed to mitochondrial stress and contributes to repressing subsequent inflammatory responses.

    • Yvonne Bordon
    Research Highlight
  • A paper in Nature Immunology describes a new subset of fibroblastic reticular cells, defined by expression of Gremlin 1, in lymphoid tissues that maintain homeostasis of conventional dendritic cells and ensure proper T cell immunity.

    • Lucy Bird
    Research Highlight
  • The currently licensed mRNA vaccines for SARS-CoV-2 can elicit cross-neutralizing antibodies against B.1.351 variants of the virus, but are less potent against these variants.

    • Yvonne Bordon
    Research Highlight
  • New research published in Immunity suggests that the increased rigidity of cancer cells during metastasis can result in a biophysical vulnerability to killing by cytotoxic lymphocytes through a form of mechanosurveillance.

    • Kirsty Minton
    Research Highlight
  • Clonal haematopoiesis — an expansion of blood cell clones due to advantageous somatic mutations — is linked to myocardial infarction. A new study shows that activation of the AIM2 inflammasome in clonally expanded macrophages exacerbates atherosclerosis by driving both proliferation and pyroptosis.

    • Lucy Bird
    Research Highlight
  • A recent study in Immunity explains the loss of T cells and consequent increased susceptibility to bacterial infection following severe tissue injury. Injury-induced AIM2 inflammasome activation causes expansion of a CD95L-expressing monocyte population, which leads to extrinsic T cell apoptosis.

    • Lucy Bird
    Research Highlight
  • Intestinal helminths can increase the lethality of a subsequent coinfection with neurotropic flaviviruses by activating tuft cells and type 2 immune mechanisms in the gut.

    • Yvonne Bordon
    Research Highlight
  • A recent study in Science describes how the innate immune sensor cGAS is inhibited by phosphorylation during mitosis to prevent an inflammatory response to self-DNA.

    • Kirsty Minton
    Research Highlight