Research Highlights

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  • A paper in Cell describes a role for regulatory T cells in mediating the symptoms of opioid withdrawal through effects on neuronal synapses.

    • Kirsty Minton
    Research Highlight
  • In breast cancer, an effective response to therapy with immune checkpoint blockade depends on T cell–eosinophil collaboration: CD4+ T cells produce IL-5 to mobilize eosinophils, which in turn help to activate antitumour CD8+ T cell responses.

    • Lucy Bird
    Research Highlight
  • Single-cell analysis of the regenerative velvet skin covering reindeer antlers during periods of growth shows that interactions between fibroblasts and immune cells determine wound healing outcomes.

    • Kirsty Minton
    Research Highlight
  • The RNA polymerase III subunit TFIIIA transcribes 5S ribosomal RNA pseudogenes that activate RIG-I. Mutations affecting TFIIIA impair antiviral immune responses and are associated with herpes simplex encephalitis.

    • Yvonne Bordon
    Research Highlight
  • Mucosal-associated invariant T (MAIT) cells are present in the meninges and help to maintain normal neural function by preserving meningeal barrier homeostasis and integrity.

    • Lucy Bird
    Research Highlight
  • Under conditions of endoplasmic reticulum stress, tumour cells release cholesterol-containing extracellular vesicles that promote the immunosuppressive functions of myeloid-derived suppressor cells.

    • Kirsty Minton
    Research Highlight
  • A new genetic model provides insights into the non-redundant functions of type 2 innate lymphoid cells.

    • Alexandra Flemming
    Research Highlight
  • An integrated systems approach involving zebrafish can be used to identify environmental factors relevant to inflammatory bowel disease.

    • Yvonne Bordon
    Research Highlight
  • Two new studies published in Cell explain how pain-sensing nociceptors regulate commensal composition and support intestinal tissue protection.

    • Lucy Bird
    Research Highlight
  • Wattrus et al. report a role for embryonic macrophages in zebrafish in promoting the death or proliferation of haematopoietic stem cells (HSCs), which regulates HSC clonality into adulthood.

    • Kirsty Minton
    Research Highlight
  • Some T cells elongate their telomeres by acquiring telomeric DNA in extracellular vesicles from antigen-presenting cells, which rescues them from senescence and supports long-term immune memory.

    • Lucy Bird
    Research Highlight
  • Diurnal rhythmicity of IgA production by intestinal plasma cells is entrained by time of feeding, with effects on composition and metabolic activity of the commensal microbiota.

    • Kirsty Minton
    Research Highlight
  • A bad diet, rich in fats and sugars, not only causes low-grade chronic inflammation but also activates antigen-specific autoreactive B and T cells that promote liver damage in the setting of type 2 diabetes.

    • Lucy Bird
    Research Highlight