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Laura Mackay describes two landmark papers by Gebhardt et al. and Masopust et al., published in 2009 and 2010, that signified the advent of tissue-resident memory T cells as a distinct T cell subset.
Adrian Liston describes two papers by Nicole Le Douarin and colleagues from the 1980s that used a chick–quail graft system to show the existence of dominant T cell tolerance.
Jeffrey Bluestone describes a 1987 study of anergic T cells by Marc Jenkins and Ron Schwartz that altered his thoughts about T cell tolerance and eventually gave birth to the field of checkpoint inhibition.
Thirumala-Devi Kanneganti describes a 2002 study by Jürg Tschopp and colleagues that first described the multiprotein, caspase-activating inflammasome complex that drives the maturation and secretion of IL-1β.
Gabrielle Belz describes a 2002 paper by Iyer et al. that linked cellular nutrient levels in cytotoxic T cells with their ability to mount a vigorous response.
Jean-Laurent Casanova describes three papers by Max Cooper and colleagues that described the convergent evolution of adaptive immunity in jawless vertebrates.
Jedd Wolchok describes a 1996 study by Alan Houghton and colleagues that showed how immune tolerance to self antigens on cancer cells could be overcome.
Shane Crotty discusses a 2013 study by Barton Haynes and colleagues that beautifully illustrates the extreme capacity of a B cell response to evolve in real time to a viral infection.