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A preprint by Zhou et al. shows that the clinical efficacy of immune checkpoint blockade in patients with cancer does not depend on the presence of tumour-draining lymph nodes, as their role is taken over by more distant lymph nodes.
Re-exposure to a previously encountered antigen leads to robust antibody responses and the formation of ‘recall’ germinal centres. A preprint by Schiepers et al. shows that antibody feedback in these germinal centres ensures the maturation of naive B cells that can target escape epitopes.
A preprint by Kim et al. shows that the brain parenchyma can be seeded with age with clonal haematopoiesis-derived monocytes that drive neuropathology.
A preprint by Kwok et al. describes the identification of common neojunction-derived antigens that could serve as targets for ‘off the shelf’ vaccines or adoptive cell therapies for patients with various types of cancer.
A preprint by Faust et al. determines mechanisms of crosstalk between adipocytes and fibroblasts in the joint relevant to the pathogenesis of osteoarthritis and rheumatoid arthritis.
A preprint by Dhariwala et al. reports that monocytes in the skin of newborn mice suppress microbiota-driven inflammatory responses by sequestering IL-1 to prevent T cell activation.
A preprint by Rakebrandt, Yassini et al. investigates the role of CD4+ T helper cells in heterologous immunity, identifying a population of memory cells that have pro-inflammatory function in a T cell receptor-independent manner.
A preprint by Ramanan et al. examines the roles of accessory transcription factors in regulating subsets of colonic regulatory T cells, independently of the microbiota and T cell specificity.
A preprint by Nakandakari-Higa et al. introduces universal LIPSTIC (uLIPSTIC), a labelling technique for the detection of physical interactions between any cell types without the requirement for specific receptor–ligand interaction.
A preprint by Sbierski-Kind et al. shows that IL-33-producing adventitial fibroblasts provide a stromal niche for ILC2s that limits IL-17-mediated liver fibrosis.
A preprint by Lad et al. shows that tumour-associated neutrophils in glioblastoma originate from skull bone marrow and acquire an antigen-presenting cell phenotype intratumorally in the presence of local T cells.
A preprint by Mahadevan et al. shows that pancreatitis alters the immune landscape of mice with pancreatic ductal adenocarcinoma and highlights a role for dendritic cells in promoting responses to immune checkpoint blockade.
A preprint by Rodríguez-Silvestre et al. describes a mechanism for the export of antigens from endosomes regulated by perforin 2, for cross-presentation by dendritic cells.
A preprint by Sikder et al. identifies a role for the maternal milk microbiota in conferring resistance to severe lower respiratory infections in offspring by promoting the development of plasmacytoid dendritic cells.
A preprint by Le Coz et al. identifies that human T follicular regulatory cells with differences in T cell suppressive and B cell helper capacities can be derived from the regulatory T cell lineage or the T follicular helper cell lineage.
A preprint by Lozano-Rabella et al. uses a proteogenomics approach to identify an underappreciated class of non-canonical tumour ligands shared across tumours.