Journal Clubs

Filter By:

Article Type
  • A preprint by Ma et al. investigates the mechanism of antigen spreading induced by a vaccine-boosted CAR T cell approach, which has implications for the therapeutic challenges associated with tumour heterogeneity or tumour antigen loss.

    • Jaime Mateus-Tique
    • Brian Brown
    Journal Club
  • A preprint by Martinez-Riano et al. evaluates the dynamics of antigen retention by follicular dendritic cells (FDCs) in germinal centres, showing that immune complexes accumulate in the centre of the FDC network.

    • Nicolas Ruffin
    • Ester Gea-Mallorquí
    Journal Club
  • A preprint by Cheng et al. describes how differential expression of the X-chromosome-encoded epigenetic regulator UTX contributes to sex-based differences in natural killer cell frequency and function.

    • Ashley Reid Cahn
    • Adam M. Farkas
    Journal Club
  • A preprint by Ho et al. investigates the role of decreased CD58 expression in cancer cell immune evasion, through both lack of T cell co-stimulation and increased T cell inhibition.

    • Max Quastel
    • Michael Dustin
    Journal Club
  • A preprint by Mosallanejad et al. uses a comparative immunology approach to investigate the catalytic domains of cGAS, showing that reactivity to self-DNA is not conserved across mammalian species.

    • Bethany Charlton
    • Ester Gea-Mallorquí
    Journal Club
  • A preprint by Baer et al. looks at the role of pancreas tissue-resident macrophages in pancreatic tissue injury and fibrosis during pancreatitis and pancreatic ductal adenocarcinoma.

    • Miriam Saffern
    • Miriam Merad
    Journal Club
  • A preprint by Daniel et al. reports a novel, late-stage phenotype of exhausted T cells that occurs concurrently with terminally differentiated exhausted T cells, determined by T cell receptor affinity for antigen.

    • Michelle A. Tran
    • Nina Bhardwaj
    Journal Club
  • A preprint by Ukita et al. describes a role for CXCL13-producing T helper cells in promoting the formation of tertiary lymphoid structures in ovarian cancer that are associated with improved clinical outcome.

    • Elena Brenna
    • Isabela Pedroza-Pacheco
    Journal Club
  • Three recent preprints investigate the entry route of SARS-CoV-2 Omicron variant into host cells and its cellular and host tropism.

    • Luisanna Pia
    • Sarah Rowland-Jones
    Journal Club
  • A preprint by Jerby-Arnon et al. uses a novel algorithm for scRNAseq data to describe a pan-cancer programme for dysfunctional tumour-infiltrating lymphocytes that predicts response to immune checkpoint blockade therapy.

    • Nicolas Ruffin
    • Andre Ortlieb Guerreiro-Cacais
    Journal Club
  • A preprint by Rookhuizen and colleagues shows that endogenous transposable elements can boost the interferon response to TLR4 stimulation.

    • Timothy O’Donnell
    • Nicolas Vabret
    Journal Club
  • Shane Crotty discusses three independent studies published in 2009 that characterized T follicular helper cells as a distinct subset of CD4+ T cells on the basis of selective expression of BCL6.

    • Shane Crotty
    Journal Club
  • Katalin Karikó describes the discovery that replacing uridine with pseudouridine renders RNA non-immunogenic. This paved the way for developing mRNA for protein replacement therapy and, surprisingly, also for mRNA-based vaccine development.

    • Katalin Karikó
    Journal Club
  • Erika Pearce reflects on some of the early studies that helped to ignite the field of immunometabolism.

    • Erika L. Pearce
    Journal Club