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Mother mice retain a small population of latent regulatory T cells from each pregnancy that remembers their offspring and protects against future pregnancy complications.
A new study shows that even a short-term switch to a low-fibre diet suppresses immunity to bacterial infection and compromises effector T cell responses.
A study in Nature reports a lactate–HIF1α–NDUFA4L2 pathway in intestinal dendritic cells that regulates the inflammatory priming of encephalitogenic T cells.
Two studies in Nature describe the mechanisms that underlie allergen avoidance behaviour in mice, linking allergen sensing in the gut to a protective behavioural response to repeated ingestion of allergen.
A study in Immunity reports that a high-fat diet in mice leads to the loss of PPARγ+ Treg cells in the skin, which exacerbates psoriasis mediated by IL-17-producing γδ T cells.
Individuals with the HLA-B*15:01 allele may have pre-existing T cells derived from seasonal coronavirus infections that cross-protect against SARS-CoV-2.
In contrast to its role in promoting immune responses to viral and bacterial infections, STING inhibits SYK-dependent cytokine production in response to fungal infection.
Gillian Griffiths and colleagues show that T cell receptor downregulation at the immune synapse occurs through ectocytosis, which terminates receptor signalling and promotes dissociation from target cells.
A combination therapy of a tumour-targeted antibody–cytokine fusion protein and a chemotherapy drug shows promising results in preclinical testing and in a phase I study in patients with recurrent glioblastoma.
Copper(ii) ions promote the metabolic and epigenetic remodelling of macrophages towards a pro-inflammatory state. A copper-binding metformin dimer showed promising results in mouse models of inflammation.
Probiotic gut bacteria can translocate to and persist in melanomas where they stimulate antitumour CD8+ T cells through the production of immunomodulatory metabolites.