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  • Individual naive B cells show heterogeneity in their response to antigen-mediated activation.

    • Yvonne Bordon
    Research Highlight
  • As we celebrate 50 years since his seminal Nature paper describing separate lineages for B cells and T cells in the chicken, Max Cooper looks back at the early discoveries that made this breakthrough possible and describes how the B cell field emerged.

    • Max D. Cooper
    Timeline
  • The germinal centre (GC) reaction is a highly complex and regulated process. As described in this Review, recent studies have revealed dynamic cellular states in the GC, the requirements for selection of B cells that express high-affinity antibodies and the recirculation of B cells between zones of the GC.

    • Nilushi S. De Silva
    • Ulf Klein
    Review Article
  • Skin immunity can be promoted by bacterial skin commensals that induce distinct CD8+T cell responses and by adipocytes that produce antimicrobial peptides.

    • Elisabeth Kugelberg
    Research Highlight
  • Type I interferons have multiple direct and indirect effects on immune cells during infectious diseases. For the most part, they protect the host against infection, but they can also have adverse effects on the host. The existence of complex cross-regulatory networks involving type I interferons helps to ensure host protection with minimum host damage.

    • Finlay McNab
    • Katrin Mayer-Barber
    • Anne O'Garra
    Review Article
  • In addition to avoiding immune attack in the primary tumour, metastatic cancer cells can harness suppressive immune cells to help promote and protect them from immune surveillance as they travel from the primary tumour site, through blood or lymphatic vessels, to the metastatic site. Thus, targeting pro-metastatic immune cells may offer new therapeutic strategies for treating the major cause of death from cancer — metastatic disease.

    • Takanori Kitamura
    • Bin-Zhi Qian
    • Jeffrey W. Pollard
    Review Article
  • The accumulation of cholesterol in macrophages and other immune cells promotes inflammatory responses. Inflammation, in turn, reduces the normal physiological excretion of cholesterol, which amplifies the inflammatory response and promotes myelopoiesis. Here, the authors detail the mechanisms by which cholesterol accumulation affects immune signalling pathways and highlight potential therapeutic interventions that may have benefits for metabolic diseases.

    • Alan R. Tall
    • Laurent Yvan-Charvet
    Review Article
  • This Review describes the immune responses that occur in the heart, explaining how different innate and adaptive immune cell populations can have beneficial or detrimental roles during cardiac tissue injury. In particular, the authors focus on the unique macrophage subsets that are found in the heart and their roles in regenerating damaged cardiac tissue.

    • Slava Epelman
    • Peter P. Liu
    • Douglas L. Mann
    Review Article
  • PTEN maintains regulatory T cell lineage stability and immune homeostasis.

    • Olive Leavy
    Research Highlight
  • RIG-I induces a type III interferon response during hepatitis B virus infection and also directly interferes with viral replication.

    • Yvonne Bordon
    Research Highlight
  • Group 2 innate lymphoid cells promote beiging of adipose tissue and protect against obesity.

    • Yvonne Bordon
    Research Highlight
  • Bacteria in the gut that cross-react with malarial parasites can induce the production of protective natural antibodies.

    • Yvonne Bordon
    Research Highlight
  • Human memory CD4+ T cells primed in vivoby pathogens or vaccines are highly heterogeneous.

    • Elisabeth Kugelberg
    Research Highlight