Browse Articles

Two papers in Nature Immunology provide a comprehensive atlas of human natural killer cells in health and in different types of cancer.

In this Comment article, organizers of the International School of Immunotherapy (Immunoschool) reflect on the experience gained from the past ten years in using online technologies for global and inclusive immunology education.

This Review by Arnold and Munitz discusses the diverse roles of eosinophils in the settings of tissue homeostasis, infection, allergy and cancer. The authors explain the molecular mechanisms that enable eosinophils to adapt to diverse tissue types and conditions, and they consider the therapeutic potential of eosinophil-depleting drugs in the clinic.

In this Viewpoint, Nature Reviews Immunology invites eight experts in the field to share their thoughts on the key questions and challenges in MDSC research.

A preprint by Ngo et al. reports a new mouse model for the constitutive depletion of pDCs, showing that pDCs are dispensable for antiviral immunity.

A preprint by Stevens et al. establishes a novel mechanism by which the gut micobiota provides protection against neonatal respiratory tract infection.

Ahmed et al. report that IL-23-dependent CTLA4 expression by ILC3s restrains T cell-mediated inflammation in the intestine.

A preprint by Kaltenbach et al. shows a role for cytoskeletal control mechanisms in contributing to the tissue maintenance of mast cells.

Here, the authors review the single-cell sequencing studies of rheumatic and allergic diseases, providing insight into disease pathogenesis, biomarkers and therapeutic targets.

An adoptive cellular therapy based on γδ T cells, which were engineered to secrete a tumour-targeting opsonin as well as an IL-15 superagonist, controlled tumour growth in a mouse model of patient-derived osteosarcoma.

A study by Nakayama et al. shows that heart failure causes epigenetic changes in haematopoietic stem cells that predispose to further heart disease and comorbidity.

Malaria remains a devastating human disease. Although malaria vaccines are available, their limited efficacy and protective duration are problematic. In this Review, the authors discuss how immunoregulatory networks that likely develop to prevent disease during malaria may also impede prevention and control measures.

CAR T cell therapy alleviates type 2 airway inflammation in mouse models of asthma.

This Comment discusses the potential effects of ultra-processed foods (UPFs) on the immune system independently of obesity, by which UPFs might dysregulate the balance between the gut microbiota and immune cells.

Recent clinical studies show that chimeric antigen receptor (CAR) T cells, best known for treating B cell malignancies, can be used to treat patients with various B cell-driven autoimmune diseases. Here, the authors update us with the progress so far and the considerations for further improving and extending their therapeutic application.

This Review provides a guide to the memory cells of the adaptive immune system, comprising memory T cells, memory B cells and plasma cells; it covers their formation, function, heterogeneity, localization, regulation and maintenance, and the crucial technological advances that allowed their discovery.

CD8⁺ T cells become exhausted when exposed to the mechanical forces of stiff solid tumours, owing to signalling through the transcription factor OSR2.

A preprint by Ben-Chetrit et al. investigates the molecular and cellular mechanisms that regulate macrophage heterogeneity in solid breast cancer tumours.

Two papers in Immunity report the effects of acetylcholine secretion by intestinal tuft cells on epithelial cells and helminths that contribute to the anti-helminth response.