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  • Lorenzo Galluzzi and colleagues discuss the molecular mechanisms through which mitochondrial dysfunction elicits inflammatory reactions, the cellular pathways that are in place to control them and how the dysregulation of these systems contributes to pathology.

    • Saverio Marchi
    • Emma Guilbaud
    • Lorenzo Galluzzi
    Review Article
  • A preprint by Cheng et al. describes how differential expression of the X-chromosome-encoded epigenetic regulator UTX contributes to sex-based differences in natural killer cell frequency and function.

    • Ashley Reid Cahn
    • Adam M. Farkas
    Journal Club
  • Vitamin D has received much interest during the COVID-19 pandemic as a potential prophylactic or therapeutic agent — but do the available data support its use?

    • Adrian R. Martineau
    • Margherita T. Cantorna
    Comment
  • IL-17 production by skin-resident γδ T cells is required for optimal HIF1α activation in damaged epithelium, leading to epithelial cell migration and re-epithelialization.

    • Kirsty Minton
    Research Highlight
  • The non-pharmaceutical interventions that were introduced to limit the spread of SARS-CoV-2 have also affected the transmission of respiratory syncytial virus, particularly its seasonality, with implications for the deployment of new monoclonal antibodies and vaccines.

    • Lucy G. Mosscrop
    • Thomas C. Williams
    • John S. Tregoning
    Comment
  • In this Review, Gorbunova and colleagues discuss the links between DNA damage, inflammation and ageing. They focus on the implications for premature ageing syndromes and multiple age-related diseases, and highlight potential therapeutic targets.

    • Yang Zhao
    • Matthew Simon
    • Vera Gorbunova
    Review Article
  • Medullary thymic epithelial cells co-opt lineage-defining transcription factors to mimic numerous peripheral cell types and express their antigens against which maturing T cells can be tolerized.

    • Lucy Bird
    Research Highlight
  • IL-17 cytokines drive biological responses that protect the host against many infections but can also contribute to host pathology in the context of infection and autoimmunity. Here, Kingston Mills highlights the different cellular sources of IL-17 and compares the pathological versus protective functions of these cytokines.

    • Kingston H. G. Mills
    Review Article
  • In early 2022, staff from the NIAID at the NIH organized a workshop focusing on the innate immune response to SARS-CoV-2. In this Viewpoint article, some of the organizers and invited speakers share their thoughts on key outcomes of this meeting.

    • Michael S. Diamond
    • John D. Lambris
    • John S. Tsang
    Viewpoint
  • As part of our Women in Immunology series, this article pays tribute to Lydia Rabinowitsch-Kempner, who is remembered not only for her work on tuberculosis and public health but also as an advocate for women’s rights.

    • Stefan H. E. Kaufmann
    Research Highlight
  • A newly identified pregnancy-specific deacetylation of maternal antibodies expands their ability to vertically transmit protection against intracellular infection in neonates.

    • Kirsty Minton
    Research Highlight
  • Myeloid cells contribute to the immunosuppressive tumour microenvironment and can be responsible for resistance to cancer immunotherapy. Here, the authors describe the current therapies that aim to modulate the functional activities of myeloid cell populations, impacting their recruitment, survival and activity in the tumour microenvironment, acting at the level of cell surface receptors, signalling pathways, epigenetic machinery and metabolic regulators.

    • Sangeeta Goswami
    • Swetha Anandhan
    • Padmanee Sharma
    Review Article