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  • A preprint by Ma et al. investigates the mechanism of antigen spreading induced by a vaccine-boosted CAR T cell approach, which has implications for the therapeutic challenges associated with tumour heterogeneity or tumour antigen loss.

    • Jaime Mateus-Tique
    • Brian Brown
    Journal Club
  • Laura Santambrogio and Pippa Marrack clarify how the mechanisms of autoreactivity in bona fide autoimmune diseases and in chronic inflammatory and metabolic conditions overlap and how are they distinguished.

    • Laura Santambrogio
    • Philippa Marrack
  • Under conditions of endoplasmic reticulum stress, tumour cells release cholesterol-containing extracellular vesicles that promote the immunosuppressive functions of myeloid-derived suppressor cells.

    • Kirsty Minton
    Research Highlight
  • Emerging data suggest a lymphoid origin of plasmacytoid dendritic cells (pDCs), which, in most cases, do not share the classical functional properties of myeloid dendritic cells. This Comment proposes that pDCs should be assigned to a subcategory of innate lymphocytes and should be referred to as interferon-producing cells.

    • Loems Ziegler-Heitbrock
    • Toshiaki Ohteki
    • Hergen Spits
  • Tumour necrosis factor (TNF) drives inflammatory responses directly by inducing inflammatory gene expression and also indirectly by inducing cell death. This article reviews the various TNF-induced cell death pathways, their mode of execution and the molecular checkpoints that control them, which is revealing new opportunities for the treatment of TNF-mediated diseases.

    • Geert van Loo
    • Mathieu J. M. Bertrand
    Review Article
  • In this Review, the authors consider the many diverse ways in which the cytokine transforming growth factor-β (TGFβ) can regulate immune responses to tumours. Despite its complex roles, therapies are being developed that target TGFβ for cancer therapy, and the authors discuss the potential of these.

    • Briana G. Nixon
    • Shengyu Gao
    • Ming O. Li
    Review Article
  • A new genetic model provides insights into the non-redundant functions of type 2 innate lymphoid cells.

    • Alexandra Flemming
    Research Highlight
  • An integrated systems approach involving zebrafish can be used to identify environmental factors relevant to inflammatory bowel disease.

    • Yvonne Bordon
    Research Highlight
  • Two new studies published in Cell explain how pain-sensing nociceptors regulate commensal composition and support intestinal tissue protection.

    • Lucy Bird
    Research Highlight
  • A preprint by Martinez-Riano et al. evaluates the dynamics of antigen retention by follicular dendritic cells (FDCs) in germinal centres, showing that immune complexes accumulate in the centre of the FDC network.

    • Nicolas Ruffin
    • Ester Gea-Mallorquí
    Journal Club
  • Social insects such as ants form a superorganism in which individual colony members cooperate for disease defence, much like the cells of an organism. Studying social insect colonies can help to determine common principles that unite the disease defences of organisms, superorganisms and societies.

    • Sylvia Cremer
    • Michael Sixt
  • Neutrophils have a central role in the pathogenesis of systemic autoimmune and autoinflammatory diseases, particularly through neutrophil extracellular trap formation. Recent research suggests novel therapeutics targeting these structures that can improve patient outcomes.

    • Gustaf Wigerblad
    • Mariana J. Kaplan
    Review Article
  • Durham and Shamji review the history and future of allergen immunotherapy for established IgE-mediated hypersensitivity to common allergens. They describe the mechanisms of immunotherapy-induced tolerance and the new strategies being explored to achieve safer, more effective, long-term tolerance.

    • Stephen R. Durham
    • Mohamed H. Shamji