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In this Review, Liston et al. discuss the biology of regulatory T cells (Treg cells) in the brain. They consider how Treg cells are recruited to the brain and their anti-inflammatory and reparative functions in brain tissue. Finally, they highlight the potential for targeting brain Treg cells to treat a range of neurological diseases.
Gary Koretzky, who was president of the American Association of Immunologists from 2021 to 2022, shares his thoughts on the responsibility of scientists to make science more accessible to a broad public, and reflects on lessons learned during the pandemic.
In this Tools of the Trade article, Leanne Arakkal (of the Ronald Germain group) describes a technique for highly multiplexed imaging of intact tissues.
This Review outlines the mechanisms by which the microbiota alters the efficacy and immunotoxicity of established and emerging cancer treatments, and discusses the benefits and limitations of microbiota-targeting interventions that are being investigated to improve patient outcomes.
Epidemiological studies and mouse models suggest that stress can affect the evolution, dissemination and outcome of malignancies. In this Review, Ma and Kroemer present insights into the complex neuro-immune interactions that link stress to cancer, with a focus on stress-associated immunomodulatory molecules, and discuss their implications for cancer therapy.
Mother mice retain a small population of latent regulatory T cells from each pregnancy that remembers their offspring and protects against future pregnancy complications.
