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  • Many viruses, including SARS-CoV-2, can induce cellular senescence and exacerbate the senescence-associated secretory phenotype, leading to detrimental hyperinflammatory responses. Here, Schmitt and colleagues discuss the role of cellular senescence in COVID-19 as well as progress in the development of therapeutic approaches to eliminate senescent cells.

    • Clemens A. Schmitt
    • Tamar Tchkonia
    • Soyoung Lee
  • Major human pregnancy disorders arise from the failure of placental trophoblast to access sufficient supplies of maternal oxygen and nutrients. Key to understanding this process are the interactions that occur early in pregnancy between trophoblast cells that invade the decidua and maternal uterine immune cells.

    • Ashley Moffett
    • Norman Shreeve
    Review Article
  • Wattrus et al. report a role for embryonic macrophages in zebrafish in promoting the death or proliferation of haematopoietic stem cells (HSCs), which regulates HSC clonality into adulthood.

    • Kirsty Minton
    Research Highlight
  • Some T cells elongate their telomeres by acquiring telomeric DNA in extracellular vesicles from antigen-presenting cells, which rescues them from senescence and supports long-term immune memory.

    • Lucy Bird
    Research Highlight
  • The ancestral strain of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has evolved into a number of variants of concern. In this Review, Wang and colleagues discuss progress in the development and characterization of broadly neutralizing antibodies to SARS-CoV-2, which may lead to new antibody therapeutics and inform the design of next-generation vaccines.

    • Yanjia Chen
    • Xiaoyu Zhao
    • Pengfei Wang
    Review Article
  • Diurnal rhythmicity of IgA production by intestinal plasma cells is entrained by time of feeding, with effects on composition and metabolic activity of the commensal microbiota.

    • Kirsty Minton
    Research Highlight
  • Three-dimensional (3D) genome organization has emerged as an important regulator of gene expression and genomic interaction. Here, the authors explain how 3D genome organization impacts immune cell development and function, and discuss how aberrant genome folding can contribute to immune-mediated disease and cancer.

    • Sergi Cuartero
    • Grégoire Stik
    • Ralph Stadhouders
    Review Article
  • A bad diet, rich in fats and sugars, not only causes low-grade chronic inflammation but also activates antigen-specific autoreactive B and T cells that promote liver damage in the setting of type 2 diabetes.

    • Lucy Bird
    Research Highlight
  • In this Review, Ng and colleagues examine the clinical, epidemiological and immunological aspects of monkeypox virus (MPXV) infections, with a focus on mechanisms of host immunity to MPXV. The authors also consider the unique epidemiological and pathological characteristics of the current non-endemic outbreak of the virus and discuss vaccines, therapeutics and outstanding research questions.

    • Fok-Moon Lum
    • Anthony Torres-Ruesta
    • Lisa F. P. Ng
    Review Article
  • Wildfires are increasing globally, with several recent catastrophic wildfires linked to climate change. Here, we consider the negative impact of the toxic contaminants arising from these fires on the immune system, with a focus on how wildfire pollution can exacerbate inflammatory diseases.

    • Cezmi A. Akdis
    • Kari C. Nadeau
  • This Review considers how the biophysical properties of a tissue are able to shape immune cell function through the process of mechanotransduction. There are multiple mechanotransduction pathways that operate in immune cells and the authors highlight these and the emerging field of mechanoimmunology.

    • Huixun Du
    • Juliet M. Bartleson
    • Manish J. Butte
    Review Article
  • There are many reasons why the development of a potent and durable vaccine to HIV-1 is exceptionally challenging, including the large genetic diversity of the virus and its complex mechanisms of immune evasion. In this Review, Haynes et al. discuss strategies for the induction of potent broadly neutralizing antibodies for HIV-1 and the steps that may be necessary for ultimate success.

    • Barton F. Haynes
    • Kevin Wiehe
    • George M. Shaw
    Review Article
  • Hybrid immunity occurs in those who have been both infected with and vaccinated against SARS-CoV-2. But how well does such hybrid immunity protect against the virus and its emerging variants?

    • Rahul Suryawanshi
    • Melanie Ott