Emerging targets in IBS

Emerging targets in IBS

Does immune activation contribute to irritable bowel syndrome?

  • Javier Aguilera-Lizarraga
  • Hind Hussein
  • Guy E. Boeckxstaens
Review Article

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  • A preprint by Ma et al. investigates the mechanism of antigen spreading induced by a vaccine-boosted CAR T cell approach, which has implications for the therapeutic challenges associated with tumour heterogeneity or tumour antigen loss.

    • Jaime Mateus-Tique
    • Brian Brown
    Journal Club
  • Laura Santambrogio and Pippa Marrack clarify how the mechanisms of autoreactivity in bona fide autoimmune diseases and in chronic inflammatory and metabolic conditions overlap and how are they distinguished.

    • Laura Santambrogio
    • Philippa Marrack
    Comment
  • Under conditions of endoplasmic reticulum stress, tumour cells release cholesterol-containing extracellular vesicles that promote the immunosuppressive functions of myeloid-derived suppressor cells.

    • Kirsty Minton
    Research Highlight
  • Emerging data suggest a lymphoid origin of plasmacytoid dendritic cells (pDCs), which, in most cases, do not share the classical functional properties of myeloid dendritic cells. This Comment proposes that pDCs should be assigned to a subcategory of innate lymphocytes and should be referred to as interferon-producing cells.

    • Loems Ziegler-Heitbrock
    • Toshiaki Ohteki
    • Hergen Spits
    Comment
  • A new genetic model provides insights into the non-redundant functions of type 2 innate lymphoid cells.

    • Alexandra Flemming
    Research Highlight
Neuroimmune connections

Neuroimmunology

A Series of articles published in Nature Reviews Immunology focusing on connections between the immune system and nervous system.
  • Lucy Bird
Series

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