Fossils of bacteria and immune components

ANCIENT DEFENCES

Tracing the bacterial origins of antiviral cell defence mechanisms 

Announcements

  • Picture of coronavirus

    NRI is 20! To celebrate this milestone, we present 20 Journal Club articles that pay tribute to some of the major immunological breakthroughs that have occurred since the journal was launched in October 2001. We also announce the launch of a new series of Perspective articles that consider the ‘past, present and future’ use of immunotherapies in different disease settings.

  • Neuroimmune Series

    The field of neuroimmunology has blossomed in recent years. This can be attributed to sophisticated technological advances as well as to the burgeoning collaboration of neuroscientists and immunologists. Articles in this Series reflect the fruits of these collaborative efforts and review our current understanding of the intricate crosstalk that takes place between the immune and nervous systems.

  • Picture of peer review

    In this Collection, we bring you articles that highlight the latest research and insight into the immunology of SARS-CoV-2 and the associated disease COVID-19. They cover our emerging understanding of the immune response to this new coronavirus, prospects for vaccine development, immunopathology of COVID-19 and how it might be treated with immunomodulatory drugs.

  • A regularly updated list of upcoming immunology conferences, including virtual meetings

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    • Many viruses, including SARS-CoV-2, can induce cellular senescence and exacerbate the senescence-associated secretory phenotype, leading to detrimental hyperinflammatory responses. Here, Schmitt and colleagues discuss the role of cellular senescence in COVID-19 as well as progress in the development of therapeutic approaches to eliminate senescent cells.

      • Clemens A. Schmitt
      • Tamar Tchkonia
      • Soyoung Lee
      Perspective
    • Major human pregnancy disorders arise from the failure of placental trophoblast to access sufficient supplies of maternal oxygen and nutrients. Key to understanding this process are the interactions that occur early in pregnancy between trophoblast cells that invade the decidua and maternal uterine immune cells.

      • Ashley Moffett
      • Norman Shreeve
      Review Article
    • The ancestral strain of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has evolved into a number of variants of concern. In this Review, Wang and colleagues discuss progress in the development and characterization of broadly neutralizing antibodies to SARS-CoV-2, which may lead to new antibody therapeutics and inform the design of next-generation vaccines.

      • Yanjia Chen
      • Xiaoyu Zhao
      • Pengfei Wang
      Review Article
    • Three-dimensional (3D) genome organization has emerged as an important regulator of gene expression and genomic interaction. Here, the authors explain how 3D genome organization impacts immune cell development and function, and discuss how aberrant genome folding can contribute to immune-mediated disease and cancer.

      • Sergi Cuartero
      • Grégoire Stik
      • Ralph Stadhouders
      Review Article
    • In this Review, Ng and colleagues examine the clinical, epidemiological and immunological aspects of monkeypox virus (MPXV) infections, with a focus on mechanisms of host immunity to MPXV. The authors also consider the unique epidemiological and pathological characteristics of the current non-endemic outbreak of the virus and discuss vaccines, therapeutics and outstanding research questions.

      • Fok-Moon Lum
      • Anthony Torres-Ruesta
      • Lisa F. P. Ng
      Review Article
  • Wattrus et al. report a role for embryonic macrophages in zebrafish in promoting the death or proliferation of haematopoietic stem cells (HSCs), which regulates HSC clonality into adulthood.

    • Kirsty Minton
    Research Highlight
  • Some T cells elongate their telomeres by acquiring telomeric DNA in extracellular vesicles from antigen-presenting cells, which rescues them from senescence and supports long-term immune memory.

    • Lucy Bird
    Research Highlight
  • Diurnal rhythmicity of IgA production by intestinal plasma cells is entrained by time of feeding, with effects on composition and metabolic activity of the commensal microbiota.

    • Kirsty Minton
    Research Highlight
  • A bad diet, rich in fats and sugars, not only causes low-grade chronic inflammation but also activates antigen-specific autoreactive B and T cells that promote liver damage in the setting of type 2 diabetes.

    • Lucy Bird
    Research Highlight
Neuroimmune connections

Neuroimmunology

A Series of articles published in Nature Reviews Immunology focusing on connections between the immune system and nervous system.
  • Lucy Bird
Series

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