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  • Picture of T cell and antigen-presenting cell

    T cells are specialized lymphocytes that have vital roles in the immune system. Since their initial description in the 1960s, they have become a major focus of immunology research. In this Nature Milestone on T cells, we explore the pivotal studies that advanced our understanding of various aspects of T cell biology, including their functions in health and disease and therapeutic potential.

  • Neuroimmune Series

    The field of neuroimmunology has blossomed in recent years. This can be attributed to sophisticated technological advances as well as to the burgeoning collaboration of neuroscientists and immunologists. Articles in this Series reflect the fruits of these collaborative efforts and review our current understanding of the intricate crosstalk that takes place between the immune and nervous systems.

  • Picture of peer review

    In this Collection, we bring you articles that highlight the latest research and insight into the immunology of SARS-CoV-2 and the associated disease COVID-19. They cover our emerging understanding of the immune response to this new coronavirus, prospects for vaccine development, immunopathology of COVID-19 and how it might be treated with immunomodulatory drugs.

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  • Commensal-specific T cells promote the regeneration of damaged sensory nerves in the skin, through an IL-17-dependent pathway.

    • Lucy Bird
    Research Highlight
  • A paper in Cell describes a role for regulatory T cells in mediating the symptoms of opioid withdrawal through effects on neuronal synapses.

    • Kirsty Minton
    Research Highlight
  • A preprint by Beltra et al. describes a role for STAT5A in the development of an intermediate-exhausted ‘effector-like’ phenotype of exhausted T cells.

    • David Arcia-Anaya
    • Tim Elliott
    Journal Club
  • In breast cancer, an effective response to therapy with immune checkpoint blockade depends on T cell–eosinophil collaboration: CD4+ T cells produce IL-5 to mobilize eosinophils, which in turn help to activate antitumour CD8+ T cell responses.

    • Lucy Bird
    Research Highlight
Neuroimmune connections

Neuroimmunology

A Series of articles published in Nature Reviews Immunology focusing on connections between the immune system and nervous system.
  • Lucy Bird
Series

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