Presenting peptides

Presenting peptides

A guide to antigen processing and presentation on MHC molecules

  • Novalia Pishesha
  • Thibault J. Harmand
  • Hidde L. Ploegh
Review Article


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  • Neuroimmune Series

    The field of neuroimmunology has blossomed in recent years. This can be attributed to sophisticated technological advances as well as to the burgeoning collaboration of neuroscientists and immunologists. Articles in this Series reflect the fruits of these collaborative efforts and review our current understanding of the intricate crosstalk that takes place between the immune and nervous systems.

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    In this Collection, we bring you articles that highlight the latest research and insight into the immunology of SARS-CoV-2 and the associated disease COVID-19. They cover our emerging understanding of the immune response to this new coronavirus, prospects for vaccine development, immunopathology of COVID-19 and how it might be treated with immunomodulatory drugs.

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  • A preprint by Ma et al. investigates the mechanism of antigen spreading induced by a vaccine-boosted CAR T cell approach, which has implications for the therapeutic challenges associated with tumour heterogeneity or tumour antigen loss.

    • Jaime Mateus-Tique
    • Brian Brown
    Journal Club
  • Laura Santambrogio and Pippa Marrack clarify how the mechanisms of autoreactivity in bona fide autoimmune diseases and in chronic inflammatory and metabolic conditions overlap and how are they distinguished.

    • Laura Santambrogio
    • Philippa Marrack
  • Under conditions of endoplasmic reticulum stress, tumour cells release cholesterol-containing extracellular vesicles that promote the immunosuppressive functions of myeloid-derived suppressor cells.

    • Kirsty Minton
    Research Highlight
  • Emerging data suggest a lymphoid origin of plasmacytoid dendritic cells (pDCs), which, in most cases, do not share the classical functional properties of myeloid dendritic cells. This Comment proposes that pDCs should be assigned to a subcategory of innate lymphocytes and should be referred to as interferon-producing cells.

    • Loems Ziegler-Heitbrock
    • Toshiaki Ohteki
    • Hergen Spits
  • A new genetic model provides insights into the non-redundant functions of type 2 innate lymphoid cells.

    • Alexandra Flemming
    Research Highlight
Neuroimmune connections


A Series of articles published in Nature Reviews Immunology focusing on connections between the immune system and nervous system.
  • Lucy Bird


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