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  • Picture of T cell and antigen-presenting cell

    Join us for a Nature Conference on cancer immunotherapy, co-organised by Dana Farber Cancer Institute, Nature Reviews Immunology, Nature Immunology, Nature Medicine and Nature Cancer, on June 10-12 2024 in Boston. Submit your abstract by April 12, 2024

  • Picture of T cell and antigen-presenting cell

    In the 1950s and 1960s, scientists performed experiments to follow lymphocytes on their journey around the body, which helped us to work out where they go and what they do. This work laid the foundation for everything we know about T cells today, including how they become activated to fight infections and how they form memory populations that provide long-lasting immunity.

  • Picture of peer review

    In this Collection, we bring you articles that highlight the latest research and insight into the immunology of SARS-CoV-2 and the associated disease COVID-19. They cover our emerging understanding of the immune response to this new coronavirus, prospects for vaccine development, immunopathology of COVID-19 and how it might be treated with immunomodulatory drugs.

  • A regularly updated list of upcoming immunology conferences, including virtual meetings

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    • In this Review, the authors discuss the origins of regulatory T (Treg) cells in the periphery and the mechanisms by which Treg cells are induced, as well as the regulation of the suppressive function of these cells. Moreover, they examine evidence for and  mechanisms of Treg cell dysfunction in common autoimmune diseases such as multiple sclerosis, inflammatory bowel disease, systemic lupus erythematosus and rheumatoid arthritis.

      • Tomokazu S. Sumida
      • Nardos T. Cheru
      • David A. Hafler
      Review Article
    • This Review highlights new insights into the biology of inflammasomes from the perspective of structural and mechanistic studies, revealing how the supramolecular complexes that activate inflammatory caspases are assembled and regulated, to induce cytokine maturation and release, as well as pyroptotic cell death.

      • Jianing Fu
      • Kate Schroder
      • Hao Wu
      Review Article
    • The first immune-targeted drug for type 1 diabetes (T1D), teplizumab, received regulatory approval by the US FDA in 2022. In this Review, Herold, Walker and colleagues examine the immune mechanisms that underpin T1D and provide an overview of immune-targeted strategies for T1D that are currently in development.

      • Kevan C. Herold
      • Thomas Delong
      • Lucy S. K. Walker
      Review Article
    • Immune cell engagers — antibody-based molecules engineered to direct immune effector cells to recognize and kill cancer cells — represent a rapidly expanding approach in cancer therapy. Here, the authors bring us up to date with the targets, challenges and opportunities for harnessing the anticancer activities of T cells, natural killer cells and myeloid cells with immune cell engagers.

      • Aurore Fenis
      • Olivier Demaria
      • Emilie Narni-Mancinelli
      Review Article
Neuroimmune connections

Neuroimmunology

A Series of articles published in Nature Reviews Immunology focusing on connections between the immune system and nervous system.
  • Lucy Bird
Series

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