Nature Reviews Immunology

Immune ageing at single-cell resolution

Current issue

Thymic masqueraders

Lucy Bird
Research Highlight 11 Jul 2022
Pregnancy-specific antibody modification

Kirsty Minton
Research Highlight 13 Jun 2022
RNA exosome essential for early B cell development

Alexandra Flemming
Research Highlight 30 Jun 2022
Considering innate immune responses in SARS-CoV-2 infection and COVID-19

Michael S. Diamond
John D. Lambris
John S. Tsang
Viewpoint 04 Jul 2022
The type I interferonopathies: 10 years on

Yanick J. Crow
Daniel B. Stetson
Review Article 20 Oct 2021
Immune ageing at single-cell resolution

Denis A. Mogilenko
Irina Shchukina
Maxim N. Artyomov
Review Article 23 Nov 2021

Contents

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Announcements

NRI at 20

NRI is 20! To celebrate this milestone, we present 20 Journal Club articles that pay tribute to some of the major immunological breakthroughs that have occurred since the journal was launched in October 2001. We also announce the launch of a new series of Perspective articles that consider the ‘past, present and future’ use of immunotherapies in different disease settings.
Neuroimmunology

The field of neuroimmunology has blossomed in recent years. This can be attributed to sophisticated technological advances as well as to the burgeoning collaboration of neuroscientists and immunologists. Articles in this Series reflect the fruits of these collaborative efforts and review our current understanding of the intricate crosstalk that takes place between the immune and nervous systems.
COVID-19 watch

In this Collection, we bring you articles that highlight the latest research and insight into the immunology of SARS-CoV-2 and the associated disease COVID-19. They cover our emerging understanding of the immune response to this new coronavirus, prospects for vaccine development, immunopathology of COVID-19 and how it might be treated with immunomodulatory drugs.
Conference calendar

A regularly updated list of upcoming immunology conferences, including virtual meetings

Latest Reviews & Analysis

- Strategies for HIV-1 vaccines that induce broadly neutralizing antibodies
  
  There are many reasons why the development of a potent and durable vaccine to HIV-1 is exceptionally challenging, including the large genetic diversity of the virus and its complex mechanisms of immune evasion. In this Review, Haynes et al. discuss strategies for the induction of potent broadly neutralizing antibodies for HIV-1 and the steps that may be necessary for ultimate success.
  
  Barton F. Haynes
  Kevin Wiehe
  George M. Shaw
  
  Review Article 12 Aug 2022
- Understanding COVID-19-associated coagulopathy
  
  Here, the authors consider our emerging understanding of COVID-19-associated coagulopathy. They focus on the complex interactions between innate immune, coagulation and fibrinolytic pathways that can lead to potentially life-threatening thrombosis following SARS-CoV-2 infection.
  Edward M. Conway
  Nigel Mackman
  James H. Morrissey
  
  Perspective 05 Aug 2022
- The roles of extracellular vesicles in the immune system
  
  Extracellular vesicles (EVs) are increasingly recognized as having ubiquitous roles in the immune system. This Review focuses on the progress made in the field in the past 5 years, including the roles of EVs in innate and adaptive immunity and their potential use in diagnosis and therapy.
  Edit I. Buzas
  
  Review Article 04 Aug 2022
- Mitochondrial control of inflammation
  
  Lorenzo Galluzzi and colleagues discuss the molecular mechanisms through which mitochondrial dysfunction elicits inflammatory reactions, the cellular pathways that are in place to control them and how the dysregulation of these systems contributes to pathology.
  Saverio Marchi
  Emma Guilbaud
  Lorenzo Galluzzi
  
  Review Article 25 Jul 2022
- DNA damage and repair in age-related inflammation
  
  In this Review, Gorbunova and colleagues discuss the links between DNA damage, inflammation and ageing. They focus on the implications for premature ageing syndromes and multiple age-related diseases, and highlight potential therapeutic targets.
  Yang Zhao
  Matthew Simon
  Vera Gorbunova
  
  Review Article 13 Jul 2022
- IL-17 and IL-17-producing cells in protection versus pathology
  Kingston H. G. Mills
  
  Review Article 05 Jul 2022
- Considering innate immune responses in SARS-CoV-2 infection and COVID-19
  Michael S. Diamond
  John D. Lambris
  John S. Tsang
  
  Viewpoint 04 Jul 2022
- Myeloid cell-targeted therapies for solid tumours
  Sangeeta Goswami
  Swetha Anandhan
  Padmanee Sharma
  
  Review Article 13 Jun 2022
- Host-directed immunotherapy of viral and bacterial infections: past, present and future
  Robert S. Wallis
  Anne O’Garra
  Andreas Wack
  
  Perspective 07 Jun 2022

News & Comment

Fungus hijacks TLR4 to build a type 2 immune niche

A fungal virulence factor promotes pathogenic type 2 immunity via Toll-like receptor 4.

Yvonne Bordon
Research Highlight 09 Aug 2022
SARS-CoV-2 hybrid immunity: silver bullet or silver lining?

Hybrid immunity occurs in those who have been both infected with and vaccinated against SARS-CoV-2. But how well does such hybrid immunity protect against the virus and its emerging variants?

Rahul Suryawanshi
Melanie Ott
Comment 09 Aug 2022
ZBP1 induces immunopathology caused by loss of ADAR1-mediated RNA editing

Three papers in Nature identify ZBP1 as a key effector of cell death and inflammation downstream of ADAR mutation, as occurs in patients with Aicardi-Goutières syndrome.

Kirsty Minton
Research Highlight 05 Aug 2022
Will anti-vaccine activism in the USA reverse global goals?

In the time of the COVID-19 pandemic, anti-vaccine activism in the USA accelerated, amplified and formed an alliance with political groups and even extremists. An organized, well-funded and empowered anti-science movement now threatens to spill over and threaten all childhood immunizations in the USA and globally.

Peter J. Hotez
Comment 01 Aug 2022
Encouraging vaccine uptake: lessons from behavioural science

Established models of behavioural science can help to explain the suboptimal COVID-19 vaccine uptake even in countries with a plentiful supply, showing that increasing vaccination is not just about increasing knowledge and motivation, but also about increasing the opportunity for vaccination.

Susan Michie
Comment 27 Jul 2022
Tissue-specific epigenomics of resident memory CD8⁺ T cells

A preprint by Buquicchio et al. looks at the chromatin landscape of memory CD8⁺ T cells over the course of their development during acute and chronic viral infections.

Thi My Hanh Luong
Marcus Buggert
Journal Club 22 Jul 2022