Simon Bradbrook

The race for a vaccine for SARS-CoV-2

A guide to the  immunological principles for the design of COVID-19 vaccine strategies and an overview of the main contenders

Latest Reviews

  • Review Article |

    Reconstitution of the immune system after depletion by chemotherapy, radiotherapy, infection or transplantation is crucial to maintain protection from infection and to respond to immune-based therapy. Here the authors describe the ways in which a diverse T cell compartment can be restored, focusing on therapeutic strategies that drive the production of new T cells.

    • Enrico Velardi
    • , Jennifer J. Tsai
    •  & Marcel R. M. van den Brink
  • Perspective |

    A number of T cell-intrinsic peripheral tolerance mechanisms (quiescence, ignorance, anergy, exhaustion, senescence and cell death) restrain autoimmunity and overactive immune responses. Here, the authors provide an integrated perspective of peripheral T cell tolerance by comparing the molecular mechanisms that govern these checkpoints and discussing their role in T cell tolerance and fate regulation.

    • Mohamed A. ElTanbouly
    •  & Randolph J. Noelle
  • Review Article |

    This Review focuses on the roles of γδ T cells in tissue homeostasis and immune surveillance. The authors discuss exciting new studies showing how γδ T cells can regulate diverse physiological responses in tissues, ranging from thermogenesis in adipose tissue to remodelling at neuronal synapses.

    • Julie C. Ribot
    • , Noëlla Lopes
    •  & Bruno Silva-Santos
  • Review Article |

    Memory B cells are critically important for the formation of protective immunity following infection or vaccination, and a better understanding of these cells may inform strategies to overcome hurdles in the development of effective vaccines. This Review discusses the signals and transcription factors that regulate the development and function of germinal centre-derived memory B cells.

    • Brian J. Laidlaw
    •  & Jason G. Cyster
  • Perspective |

    How does the discovery of SARS-CoV-2 cross-reactive T cells in unexposed individuals change our understanding of the COVID-19 pandemic? In this Perspective, the authors provide a thought experiment to explain why the discovery of cross-reactive T cells may affect disease severity in individuals, but is unlikely to change our estimate of the herd immunity threshold.

    • Marc Lipsitch
    • , Yonatan H. Grad
    • , Alessandro Sette
    •  & Shane Crotty
  • Review Article |

    A transcription factor network triggered by Notch signalling in the thymus guides proliferating, multipotent progenitor cells into the T cell pathway. This Review describes how these factors work to establish regulatory target specificity, epigenomic impact and irreversibility for T cell identity.

    • Hiroyuki Hosokawa
    •  & Ellen V. Rothenberg

News & Comment



Simon Bradbrook


A Series of articles published in Nature Reviews Immunology focusing on connections between the immune system and nervous system.

Lucy Bird

Nature events Directory