Simon Bradbrook

Get rhythm!

Keeping time in group 3 innate lymphoid cells.

Latest Reviews

  • Perspective |

    In this Perspective, Alon and colleagues discuss how insights into immune cell trafficking during pneumotropic influenza virus infections may inform our understanding of immune cell recruitment to the respiratory tract in patients with coronavirus disease 2019 (COVID-19). Moreover, they examine the emerging knowledge of vascular pathologies beyond the lung caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

    • Ronen Alon
    • , Mike Sportiello
    • , Stav Kozlovski
    • , Ashwin Kumar
    • , Emma C. Reilly
    • , Alexander Zarbock
    • , Natalio Garbi
    •  & David J. Topham
  • Review Article |

    Cell death recognition can result in a multitude of distinct effector responses. Here, the authors discuss a framework for determining the specific effector response to cell death that relies on its recognition, contextual environmental signals and the identity of the efferocyte.

    • Carla V. Rothlin
    • , Thomas D. Hille
    •  & Sourav Ghosh
  • Review Article |

    Glucocorticoid treatment is used to suppress the immune system in various disease settings. However, endogenous glucocorticoids are able to promote as well as inhibit different aspects of T cell immunity. Here, the authors discuss the many ways in which T cell responses are shaped by glucocorticoids.

    • Matthew D. Taves
    •  & Jonathan D. Ashwell
  • Review Article |

    Are you new to virus research and trying to interpret the ever-expanding literature on immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)? Here, the authors compare the different assays and animal models used to measure immunity to SARS-CoV-2 infection and reconcile differences in apparent potency of antibodies assessed in different assays.

    • David S. Khoury
    • , Adam K. Wheatley
    • , Mitchell D. Ramuta
    • , Arnold Reynaldi
    • , Deborah Cromer
    • , Kanta Subbarao
    • , David H. O’Connor
    • , Stephen J. Kent
    •  & Miles P. Davenport
  • Review Article |

    Reconstitution of the immune system after depletion by chemotherapy, radiotherapy, infection or transplantation is crucial to maintain protection from infection and to respond to immune-based therapy. Here the authors describe the ways in which a diverse T cell compartment can be restored, focusing on therapeutic strategies that drive the production of new T cells.

    • Enrico Velardi
    • , Jennifer J. Tsai
    •  & Marcel R. M. van den Brink
  • Perspective |

    A number of T cell-intrinsic peripheral tolerance mechanisms (quiescence, ignorance, anergy, exhaustion, senescence and cell death) restrain autoimmunity and overactive immune responses. Here, the authors provide an integrated perspective of peripheral T cell tolerance by comparing the molecular mechanisms that govern these checkpoints and discussing their role in T cell tolerance and fate regulation.

    • Mohamed A. ElTanbouly
    •  & Randolph J. Noelle

News & Comment

Series

Neuroimmunology

Simon Bradbrook

Neuroimmunology

A Series of articles published in Nature Reviews Immunology focusing on connections between the immune system and nervous system.

Lucy Bird

Naturejobs.com

Nature events Directory