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Extravesicular vesicles and their roles in the immune system


  • Picture of T cell and antigen-presenting cell

    T cells are specialized lymphocytes that have vital roles in the immune system. Since their initial description in the 1960s, they have become a major focus of immunology research. In this Nature Milestone on T cells, we explore the pivotal studies that advanced our understanding of various aspects of T cell biology, including their functions in health and disease and therapeutic potential.

  • mast cell degranulating

    Join us at The Crick in London on the evening of Thursday 27th April for a public outreach event on allergy to celebrate World Immunology Day 2023. Free to attend, register via link.

  • Picture of peer review

    In this Collection, we bring you articles that highlight the latest research and insight into the immunology of SARS-CoV-2 and the associated disease COVID-19. They cover our emerging understanding of the immune response to this new coronavirus, prospects for vaccine development, immunopathology of COVID-19 and how it might be treated with immunomodulatory drugs.

  • A regularly updated list of upcoming immunology conferences, including virtual meetings


    • In the spleen, diverse types of fibroblastic stromal cells, as well as neuronal cells, establish a complex microanatomy that supports splenic function at homeostasis and orchestrates immune responses to infection.

      • Yannick O. Alexandre
      • Scott N. Mueller
      Review Article
    • Here, Ting and colleagues provide an overview of the NLR gene family, detailing the initial discovery of NLRs and the key experiments that uncovered their biology. NLRs are well known for their roles as inflammasome receptors and regulators of inflammation but they also have less appreciated roles, for example, in embryogenesis and reproduction.

      • Wei-Chun Chou
      • Sushmita Jha
      • Jenny P.-Y. Ting
      Review Article
    • Clonal haematopoiesis — the occurrence of somatic mutations and mosaic chromosomal alterations in blood cells — is associated with age-related diseases, autoimmunity, immunodeficiency and haematological neoplasms. This Review describes how myeloid and lymphoid cell dysregulation underlies this association.

      • Roger Belizaire
      • Waihay J. Wong
      • Benjamin L. Ebert
      Review Article
    • Macrophages are important for host immunity to infections and for clearing waste products from tissues, but they also maintain tissue health by regulating metabolism, neuronal functions and many other biological processes. Here, Elvira Mass and co-workers discuss the different tissue-specific macrophage populations that are found throughout the body, highlighting shared and unique aspects of their developmental trajectories, transcriptional programmes and physiological functions.

      • Elvira Mass
      • Falk Nimmerjahn
      • Andreas Schlitzer
      Review Article
    • Koohy and co-workers discuss how we must turn to machine-learning approaches to define the antigen specificity of the many millions of possible T cell receptors. They review the models and methods currently being used to predict cognate antigens for orphan T cell receptors.

      • Dan Hudson
      • Ricardo A. Fernandes
      • Hashem Koohy
Neuroimmune connections


A Series of articles published in Nature Reviews Immunology focusing on connections between the immune system and nervous system.
  • Lucy Bird


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