Simon Bradbrook


Laura Walker and Dennis Burton highlight the new generation of highly potent antibodies that are being developed to tackle viral infections.

Latest Reviews

  • Review Article |

    This Review considers the importance of the core circadian clock for regulating both innate and adaptive immune cell responses. The authors consider the implications for vaccination and other clinical strategies, highlighting the emerging field of chrono-immunotherapy.

    • Christoph Scheiermann
    • , Julie Gibbs
    • , Louise Ince
    •  & Andrew Loudon
  • Perspective |

    This Timeline looks back at the past 60 years of fundamental research into the mechanisms of T cell-mediated cytotoxicity, which has culminated in recent interest in the therapeutic manipulation of cytotoxic T cell responses for cancer immunotherapy.

    • Pierre Golstein
    •  & Gillian M. Griffiths
  • Review Article |

    Jamie Rossjohn and colleagues review the structural and functional data that provide insight into the MHC restriction of T cell receptors. They discuss the non-mutually exclusive contributions of intrinsic germline-encoded motifs and developmental selection to MHC restriction.

    • Nicole L. La Gruta
    • , Stephanie Gras
    • , Stephen R. Daley
    • , Paul G. Thomas
    •  & Jamie Rossjohn
  • Review Article |

    Drugs that target the cytokines that drive asthma and chronic obstructive pulmonary disease offer relief to some people with these diseases. However, as discussed here, further success will require a better understanding of the disease mechanisms and selection of the right drug for the right patient.

    • Peter J. Barnes
  • Review Article |

    Recently discovered roles for C-type lectins in development, homeostasis, cell death, cancer and autoimmune and inflammatory diseases extend the functions of this superfamily beyond their well-recognized involvement in antimicrobial responses.

    • Gordon D. Brown
    • , Janet A. Willment
    •  & Lauren Whitehead
  • Review Article |

    Nonhuman primates (NHPs) are increasingly used as models of human viral infections. Here, Estes and colleagues introduce different NHP models, summarize the similarities and differences between human and NHP immune systems and discuss important examples of human viruses that can be modelled in NHPs.

    • Jacob D. Estes
    • , Scott W. Wong
    •  & Jason M. Brenchley

News & Comment

  • Research Highlight |

    Natural influenza virus infection in humans induces protective neuraminidase-reactive antibodies that are not induced by current influenza vaccines.

    • Yvonne Bordon
  • Journal Club |

    Jean-Laurent Casanova describes three papers by Max Cooper and colleagues that described the convergent evolution of adaptive immunity in jawless vertebrates.

    • Jean-Laurent Casanova
  • Research Highlight |

    SAMHD1 promotes the degradation of nascent DNA strands to protect against aberrant activation of the pro-inflammatory cGAS–STING pathway by self DNA.

    • Yvonne Bordon
  • Research Highlight |

    Norovirus infection of tuft cells in the intestinal epithelium can be promoted by type 2 cytokines.

    • Kirsty Minton
  • Research Highlight |

    Strain-specific recognition of different UL40 peptides determines the proliferation and activation of NKG2C+ NK cells during HCMV infection.

    • Kirsty Minton
  • Research Highlight |

    The immunomodulatory drug dimethyl fumarate blocks GAPDH and aerobic glycolysis in activated immune cells.

    • Yvonne Bordon


Cancer immunotherapy

A Focus issue of Nature Reviews Immunology highlighting the latest advances in cancer immunotherapy, including checkpoint blockade, cancer vaccines and modulation of the tumour microenvironment to improve the efficacy of immunotherapy.

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