Simon Bradbrook


Type 2 immunity in tissue repair and fibrosis

Latest Reviews

  • Opinion |

    Normalization of the tumour vasculature can improve immune effector cell infiltration, leading to immunotherapy potentiation. In this Opinion article, Huang et al. propose that reciprocal regulation between tumour vascular normalization and immune reprogramming forms a positive feedback loop that can induce durable antitumour immunity within the tumour microenvironment.

    • Yuhui Huang
    • , Betty Y. S. Kim
    • , Charles K. Chan
    • , Stephen M. Hahn
    • , Irving L. Weissman
    •  & Wen Jiang
  • Review |

    Although systemic infection is a hallmark of malaria disease, less is known regarding how parasitized erythrocytes interact locally with host tissues. In this Review, the authors discuss how infected erythrocytes reach different tissue environments and cause specific pathological consequences in malaria.

    • Cevayir Coban
    • , Michelle Sue Jann Lee
    •  & Ken J. Ishii
  • Review |

    Technological advances have given valuable insight into the molecular mechanisms that underpin the association between HLA genetics and disease. Dendrou and colleagues review mechanisms of HLA–peptide–T cell receptor binding in health and disease and discuss how this knowledge may be translated into clinical benefit.

    • Calliope A. Dendrou
    • , Jan Petersen
    • , Jamie Rossjohn
    •  & Lars Fugger
  • Review |

    Peptidoglycan is an important structural component of bacterial cell walls, and mammalian cells express a number of distinct pattern-recognition receptors that detect peptidoglycan fragments. Here, the authors discuss new insights into the role of peptidoglycan recognition in inflammation, metabolism and disease.

    • Andrea J. Wolf
    •  & David M. Underhill
  • Review |

    Heeding the adage “prevention is better than cure”, Olivera J. Finn proposes that vaccinating individuals who have pre-malignant lesions gives the immune system the upper hand and can prevent progression to cancer.

    • Olivera J. Finn
  • Review |

    The development of multiphoton intravital microscopy has enabled detailed studies of humoral responses within lymphoid tissues. Here, Kuka and Iannacone cover recent studies of the viral subversion of B cell responses and discuss how these findings relate to our understanding of B cell activation within secondary lymphoid organs.

    • Mirela Kuka
    •  & Matteo Iannacone

News & Comment

  • Year in Review |

    Monocytes and tissue macrophages represent two main branches of the mononuclear phagocyte system, and they have complementary roles during immunological challenges. Several studies published in 2017 highlighted the distinct properties of these two cell types and furthered our understanding of their development and cellular functions.

    • Steffen Jung
  • Year in Review |

    Over the past few years, interest in the field of neuroimmunology has expanded dramatically, thanks largely to new technologies that have advanced our understanding of the intimate connections between the nervous and immune systems. Here, we highlight key advances in 2017 that have defined new roles for microglia in brain maintenance, for cytokines as neuromodulators and for the immune system in peripheral nerve activity.

    • Jonathan Kipnis
    •  & Anthony J. Filiano

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