Simon Bradbrook

Spatial Relationships

How dendritic cell location shapes T cell programming

Latest Reviews

  • Review Article |

    Double-strand breaks in DNA generated during the normal assembly and diversification of lymphocyte antigen receptor genes or by genotoxic agents during infection activate DNA damage responses. Besides repairing damaged DNA, these responses trigger important signalling events that regulate immune cell development and function.

    • Jeffrey J. Bednarski
    •  & Barry P. Sleckman
  • Review Article |

    Recent advances in systems immunology are beginning to elucidate the quantitative rules that govern cytokine-mediated cell-to-cell communication. This Review describes how combining theoretical analysis with experimental validation can lead to a better understanding of cytokine-mediated communication between cells of the immune system.

    • Grégoire Altan-Bonnet
    •  & Ratnadeep Mukherjee
  • Review Article |

    In this Review, DeNardo and Ruffell describe how macrophages shape local immune responses in the tumour microenvironment to both suppress and promote immunity to tumours. The authors also discuss the potential of targeting tumour-associated macrophages to enhance antitumour immune responses.

    • David G. DeNardo
    •  & Brian Ruffell
  • Review Article |

    Diversification of the antibody repertoire is well known to be driven by genetic recombination and mutation. However, it is becoming apparent that other processes can also diversify antibody specificities. Here, Dimitrov and colleagues discuss these unconventional strategies for antibody diversification and consider why these extra strategies have evolved.

    • Alexia Kanyavuz
    • , Annaelle Marey-Jarossay
    • , Sébastien Lacroix-Desmazes
    •  & Jordan D. Dimitrov
  • Review Article |

    During an immune response, macrophage metabolism is diverted to produce the metabolite itaconate, which has anti-inflammatory effects. This Review recounts the story of itaconate, from its discovery to its potentially far-reaching consequences for immunity, host defence and tumorigenesis.

    • Luke A. J. O’Neill
    •  & Maxim N. Artyomov

News & Comment

  • Research Highlight |

    Stefan Feske and colleagues show that calcium signalling in TH17 cells promotes a pathogenic phenotype by regulating mitochondrial function and the antioxidant response.

    • Kirsty Minton
  • Research Highlight |

    Natural killer cells can promote degeneration of injured axons and reduce post-injury hypersensitivity following peripheral nerve injury.

    • Yvonne Bordon
  • Research Highlight |

    A new study in Science identifies nemuri (nur) as encoding a secreted factor in Drosophila that has both antimicrobial and sleep-inducing properties, thus providing a direct link between sleep homeostasis and the response to infection.

    • Kirsty Minton
  • Research Highlight |

    Having a fever helps T cells reach the site of infection, thanks to thermal sensing by heat shock proteins and induction of integrin-mediated T cell migration.

    • Lucy Bird
  • Research Highlight |

    The short-chain fatty acid butyrate, derived from commensal bacteria in the gut, is shown to be a specific inducer of intestinal macrophage microbicidal functions.

    • Alexandra Flemming
  • Research Highlight |

    Intestinal intraepithelial lymphocytes regulate systemic metabolism by limiting the bioavailability of GLP1.

    • Yvonne Bordon

Collection

Year in Review

Simon Bradbrook

Year in Review

This Collection from Nature Reviews Immunology presents a series of specially commissioned ‘Year in Review’ articles that highlight the key advances in hot topics in immunology in 2018.

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