Volume 6 Issue 1, January 2009


Research Highlights

Practice Points


  • Viewpoint |

    Nonalcoholic fatty liver disease (NAFLD) is one of the most common diseases of the Western world, and is associated with an increased risk of cardiovascular disease. The beneficial effects of moderate wine consumption on cardiovascular function are well known. This Viewpoint article discusses potential risks and benefits of alcohol consumption in patients with NAFLD.

    • Margaret S Sozio
    • , Naga Chalasani
    •  & Suthat Liangpunsakul


  • Review Article |

    In the past 15 years there has been continuous improvement in outcome after orthotopic liver transplantation (OLT). As such, the recognition and prevention of long-term post-OLT complications—rejection episodes, recurrence of underlying liver disease and the adverse effects of immunosuppression—have become ever more important. This Review suggests guidelines for the management of OLT recipients to improve long-term survival, overall outcome and health-related quality of life.

    • Daniel Benten
    • , Katharina Staufer
    •  & Martina Sterneck
  • Review Article |

    Even after complete resection of nonmetastatic pancreatic cancer, recurrence rates are high. Combined modality therapy including radiation therapy reduces the recurrence rate and improves disease-free survival for several types of tumor of the gastrointestinal tract, but the use of adjuvant radiotherapy for pancreatic cancer is controversial. In this Review, the authors discuss the studies—prospective and retrospective—and the issues surrounding the use of adjuvant radiotherapy for pancreatic cancer.

    • Ruchika Gutt
    • , Stanley L Liauw
    •  & Ralph R Weichselbaum
  • Review Article |

    In the past few years, newly developed technologies have improved endoscopic recognition of the duodenum, making possible the real-time recognition of the duodenal villous pattern during upper endoscopy. This Review highlights the progress made that could be helpful for the diagnosis of celiac disease, including the development of the water-immersion technique, high-resolution magnification endoscopy, chromoendoscopy, optical band imaging, optical coherence tomography and confocal endomicroscopy.

    • Giovanni Cammarota
    • , Paolo Fedeli
    •  & Antonio Gasbarrini

Case Study

  • Case Study |

    This Case Study considers a 51-year-old male who developed unilateral hearing loss while taking pegylated interferon and ribavirin for the treatment of chronic hepatitis C infection. The patient was treated with prednisone and continued with his antiviral therapy. Improvement in the patient's hearing was achieved within a few days, and full recovery was achieved within 2 months.

    • Vu Le
    • , Ted Bader
    •  & Javid Fazili