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Disrupted sleep is reported by many patients with IBS, yet the role of sleep in IBS is not defined. This Viewpoint article discusses the subjective and objective evidence for disrupted sleep in patients with IBS, examines the relationship between gastrointestinal symptoms and sleep disturbance, and highlights areas for future research.
This Review summarizes current understanding of nonalcoholic fatty liver disease, which is now accepted as the hepatic manifestation of metabolic syndrome. The authors consider the evaluation of patients at risk of developing nonalcoholic fatty liver disease, including the assessment of risk factors, the application of imaging modalities and the role of liver biopsy, as well as potential treatment approaches.
Numerous drugs can damage the gastrointestinal tract, and improved recognition of drug-induced gastrointestinal tract pathology is needed to improve patient care. The authors of this Review discuss the most common and well-described drug-related clinicopathological conditions of the gastrointestinal tract. Much discussion is dedicated to NSAIDs—the most commonly prescribed drugs and consequently the drugs most commonly associated with gastrointestinal tract toxicity.
Pancreatic stellate cells are the main mediator of fibrogenesis during chronic pancreatitis, and chronic pancreatitis is a consistent risk factor for pancreatic ductal adenocarcinoma. In this Review, the authors discuss the idea that pancreatic stellate cells have a linking role in the development of pancreatic ductal adenocarcinoma via their ability to communicate with inflammatory cells, acinar cells and pancreatic cancer cells.
