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Volume 20 Issue 5, May 2023

Gene therapy for liver diseases, inspired by the Review on p288.

Cover design: Laura Marshall

Clinical Outlook

  • The feasibility of long-term organ preservation ex vivo has been reported for the first time with proof of concept in human transplantation. Here, we discuss the possible applications of this novel technology in the clinical setting.

    • Dilmurodjon Eshmuminov
    • Pierre-Alain Clavien
    Clinical Outlook


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Research Highlights

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  • There is an increasing burden of gastrointestinal cancers in East Asia. This Review provides an updated summary of the epidemiology of gastrointestinal cancers in this region and discusses risk factors and implications for prevention.

    • Junjie Huang
    • Don Eliseo Lucero-Prisno III
    • Martin C. S. Wong
    Review Article
  • The therapeutic landscape of metastatic colorectal cancer (mCRC) is changing. This Review provides a comprehensive overview discussing the current mCRC advances in precision oncology and suggests a treatment strategy for mCRC with rare genomic alterations.

    • Hideaki Bando
    • Atsushi Ohtsu
    • Takayuki Yoshino
    Review Article
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