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The recent increase in unexplained acute hepatitis in children in 2022 has focused attention on acute paediatric liver disease. We discuss emerging evidence and leading causal hypotheses in context with potential long-term effects of the COVID-19 pandemic for young children.
Microbiota profiling using stool samples is limited in its ability to represent intestinal microbial dynamics. CRISPR-engineered bacteria can be used to acquire cellular RNAs and create a gene expression ‘memory’ during gastrointestinal transit, with the potential to capture microbial transcriptomic changes in the gastrointestinal tract without invasive sampling.
In this Viewpoint, members of the Association of Black Gastroenterologists and Hepatologists discuss inclusivity and equity in academic medicine and give advice to Black students interested in a career in science or medicine.
In this Review, O’Toole and colleagues discuss the composition and function of the gut microbiome as it relates to ageing and ‘unhealthy’ ageing as well as the potential for microbiome-directed interventions to encourage ‘healthy’ ageing.
Polycystic liver diseases are genetic disorders that cause hepatic cystogenesis, which can coincide with cyst development in the kidney, with women being more affected than men. This Review discusses the genetics and underlying mechanisms and provides up-to-date therapeutic insights.
In this Review, Souza and Spechler describe the mechanisms, pathophysiology and cells of origin of Barrett oesophagus, a precursor of oesophageal adenocarcinoma, and discuss the clinical implications.
