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Only 12 high-income countries are on track to meet the World Health Organization’s goal of eliminating hepatitis C as a public health threat by 2030, and micro-elimination opportunities in high-risk populations in settings such as hospitals are often overlooked. We propose ten steps to eliminate hepatitis C in hospitals.
Hepatitis C virus (HCV) infection is common among people who are incarcerated in low- and middle-income countries. Prison policy changes towards HCV testing and treatment are pivotal for social justice and can be a crucial step for achieving HCV global elimination targets.
New data demonstrate racial and ethnic disparities in access to prescription medications in persons with chronic liver disease in the USA. Here, we discuss potential health equity solutions that address structural and social determinants of health to mitigate liver health inequities in access to liver disease pharmacotherapies.
Owing to its simplicity, dextran sulfate sodium (DSS)-induced colitis is one of the most widely used mouse models of colitis. However, the severity of inflammation varies from one experiment to another. In a new study, Forster and colleagues have provided new insights into the DSS model by revealing specific microbial taxa that underlie disease variability.
Attaining mucosal healing without immunosuppression is an attractive option for the treatment of inflammatory bowel disease (IBD). This Review describes the mechanisms of mucosal healing and how they might be altered in IBD and discusses potential therapeutic approaches to promote mucosal healing and regeneration.
Clostridioides difficile infection has a notable health and economic burden worldwide. In this Review, the authors provide insights into the physiology of C. difficile and how it survives and has adapted to the gut environment, including insights into host–microorganism and microorganism–microorganism relationships.
Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide and screening is useful for early diagnosis. This Review outlines currently available CRC screening options worldwide (including colonoscopy and stool-based tests). Key features of each modality and new screening tests under development are described.
The history of hepatitis C virus (HCV) is a role model for successful basic, translational and clinical research. In this Perspective, the authors chart a timeline of breakthroughs in hepatitis C research, from discovery to cure.