Volume 14 Issue 8, August 2017

Volume 14 Issue 8

Cover image supplied by Carolina Tropini, Sonnenburg Group, Stanford University, USA, who is funded by a James S. McDonnell fellowship. Fluorescent in situ hybridization of mouse colon colonized with gnotobiotic microbiota. Tissue was stained by DAPI and the mucus labelled with UEA-1 (Ulex europaeus agglutinin I), bacteria were labelled with fluorescent DNA probes.

Editorial

Comment

  • Comment |

    More people die from viral hepatitis than from HIV, yet the public health response is lacking. The ACHIEVE Coalition urges governments in Europe and elsewhere to improve hepatitis B and hepatitis C monitoring so that a reliable evidence base will be available to guide the drive towards disease elimination.

    • Jeffrey V. Lazarus
    • , Kelly Safreed-Harmon
    • , Massimo Colombo
    • , Tatjana Reic
    • , Eberhard Schatz
    • , Pierre van Damme
    •  & on behalf of the ACHIEVE Coalition
  • Comment |

    In April 2015, in partnership with the US Centers for Disease Control and Prevention and Gilead Sciences, the country of Georgia launched the world's first national HCV elimination programme, aiming to reduce HCV prevalence by 90% by 2020. After 2 years of progress, how can the Georgia experience inform global approaches to eliminating HCV?

    • Muazzam Nasrullah
    • , David Sergeenko
    • , Amiran Gamkrelidze
    •  & Francisco Averhoff

Research Highlights

News and Views

Reviews

  • Review Article |

    Extracellular vesicles have emerged as having key roles in liver disease. In this Review, Szabo and Momen-Heravi discuss the functions of extracellular vesicles in liver disease pathogenesis and progression, and explore their potential use as biomarkers, therapeutic targets and tools for therapy delivery.

    • Gyongyi Szabo
    •  & Fatemeh Momen-Heravi
  • Review Article |

    Gastric cancer is a deadly malignancy and accumulating evidence suggests that epigenetic abnormalities promote carcinogenesis. Here, the authors summarize the gastric cancer epigenome, highlighting key advances from studies of DNA methylation and histone modifications, and how these findings might lead to therapeutic opportunities.

    • Nisha Padmanabhan
    • , Toshikazu Ushijima
    •  & Patrick Tan
  • Review Article |

    The clinical management of refractory eosinophilic oesophagitis (EoE) is challenging, owing to the limited data available to guide decision-making. In this Review, Dellon discusses the clinical definition of refractory EoE, examines the causes and predictors of non-response, and highlights both current and emerging treatment modalities for non-responders.

    • Evan S. Dellon

Consensus Statement