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Elucidating the entire complexity of biological functions in the liver is vital to understand its key role in the progression of complex diseases. A new mouse study integrates complementary '–omics' data across various environmental states using the liver as a platform for multiomics analysis and identifies new mechanisms in hepatic mitochondrial function.
The global burden of malnutrition (undernutrition, micronutrient deficiencies or obesity) is considerable and associated with risk of excess mortality and long-term adverse outcomes. Concerted action to achieve agreed global nutrition targets is proposed for the next decade, which must be coupled with the political will to address the root causes of malnutrition and implement evidence-based strategies.
Obesity is a risk factor for several noncommunicable diseases, but some individuals with obesity remain metabolically healthy throughout life; whether these individuals are at risk of developing NAFLD is uncertain. In a new study, Chang et al. showed a statistically significant, graded relationship between BMI and NAFLD in metabolically healthy individuals.
This Review comprehensively examines the possible mechanisms that might link pulmonary disease and oesophageal reflux, highlighting the gaps in current knowledge and limitations of previous research, and helping to shed light on the frequent failure of antireflux treatments in pulmonary disease.
Gastrointestinal dysfunction is very common in patients with systemic sclerosis, and often severely reduces quality of life. In this Review, Emmanuel discusses optimal strategies to identify and manage gastrointestinal complications in patients with systemic sclerosis, and outlines potential new therapies.
Liver regeneration is important in both the context of homeostasis and in recovery from disease or injury. In this Review, Forbes and Newsome describe the mechanisms underlying liver regeneration and the experimental models used to study this process, as well as discussing how liver regeneration is clinically relevant.
Most colorectal polyps can now be resected endoscopically using either mucosal resection or submucosal dissection. Although the former is an established technique, the latter has seen slow adoption in the West. In this Review, the authors summarize the indications for both procedures and discuss new advances in endoscopic polyp surgery.