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Some studies have cast doubt on the effectiveness of colonoscopy at reducing the incidence and mortality of proximal colorectal cancer (CRC), as relatively high incidence rates of these cancers are found after colonoscopy—referred to as interval cancers. In this article, the current literature regarding the incidence of, and potential explanations for, interval CRCs is outlined. Piecing together the most common technical and biological explanations could provide important feedback for the medical community.
