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This Viewpoint discusses the limited effectiveness of standard medical treatments for IBS, which leave about half of patients without satisfactory symptom relief. The article argues that adjunctive psychological therapies might enhance overall IBS outcomes as evidence suggests that psychological treatments can provide long-lasting symptom improvement for the majority of patients with IBS that is refractory to medical treatment.
Home parenteral nutrition (HPN) has advanced since its introduction in the late 1960s, such that patients with intestinal failure can now survive and lead productive lives outside the hospital. This Review considers the indications for HPN, the complications that can arise, and the quality of life of patients on HPN.
The authors of this Review focus on non-malignant portal vein thrombosis (PVT), the second most common cause of portal vein occlusion. Discussion includes how the two different forms of PVT—acute and chronic—are diagnosed, how they can be treated and what the outcomes are. PVT in the setting of cirrhosis and liver transplantation is also discussed.
Celiac disease has previously been regarded as a benign intestinal disorder that can be easily treated by a gluten-free diet. This Review article discusses advances in the understanding of the genetics and immunology of celiac disease, and considers evidence for the independent existence of the adaptive and innate immune response to gluten.
