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KRAS mutations and hepatic recurrence after treatment of colorectal liver metastases

Nature Reviews Gastroenterology & Hepatology volume 14, pages 638–639 (2017)Cite this article

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Non-anatomical resection of colorectal liver metastases is the current preferred approach to maximize sparing of the hepatic parenchyma. A new study raises the question of whether resection in patients with KRAS-mutated colorectal liver metastases should be performed along segmental, anatomical lines to reduce the risk of local liver recurrence.

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Figure 1: CT imaging of a RAS-mutant colorectal liver metastasis.

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Acknowledgements

The authors thank Ruth Haynes for help in preparing the manuscript.

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Authors and Affiliations

  1. Department of Hepato-Pancreato-Biliary Surgery, Oslo University Hospital, PO Box 4950, Nydalen, 0424, Oslo, Norway

    Kristoffer Watten Brudvik

  2. Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1484, Houston, 77030, Texas, USA

    Jean-Nicolas Vauthey

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  1. Kristoffer Watten Brudvik
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Correspondence to Jean-Nicolas Vauthey.

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Brudvik, K., Vauthey, JN. KRAS mutations and hepatic recurrence after treatment of colorectal liver metastases. Nat Rev Gastroenterol Hepatol 14, 638–639 (2017). https://doi.org/10.1038/nrgastro.2017.129

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