Review Articles

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  • Advances in single-cell technologies and lineage tracing have improved our understanding of liver development. In this Review, Hoodless and colleagues discuss the formation of liver parenchymal and non-parenchymal cell types, and describe emerging parallels between early liver development and the pathogenesis of liver injury.

    • Jeremy Lotto
    • Tabea L. Stephan
    • Pamela A. Hoodless
    Review Article
  • Increased intestinal permeability owing to tight junction barrier loss could be targeted in gastrointestinal diseases associated with increased permeability. In this Review, the authors discuss the molecular components and regulation of the tight junction, and consider the relevance to gut diseases and therapeutic opportunities.

    • Arie Horowitz
    • Sandra D. Chanez-Paredes
    • Jerrold R. Turner
    Review Article
  • In this Review, Pabst and colleagues discuss the gut–liver axis, with an emphasis on the establishment and regulation of structural and functional barriers, dynamics within the axis (immune responses and microbiome) and clinical implications.

    • Oliver Pabst
    • Mathias W. Hornef
    • Tony Bruns
    Review Article
  • IL-12 and IL-23 have been implicated in inflammatory bowel disease. In this Review, Vande Casteele and colleagues summarize the mechanistic role of IL-12 and IL-23 in inflammatory bowel disease, and discuss the clinical development of drugs targeting IL-12 and/or IL-23.

    • Bram Verstockt
    • Azucena Salas
    • Stefania Vetrano
    Review Article
  • Macrophages are critical for maintaining intestinal homeostasis, yet are implicated in chronic intestinal inflammation. This Review provides detailed insights into the biology of macrophages in the context of inflammatory bowel disease and discusses future perspectives.

    • Lizi M. Hegarty
    • Gareth-Rhys Jones
    • Calum C. Bain
    Review Article
  • The treatment landscape of inflammatory bowel disease (IBD) is constantly evolving, including among pregnant women and those who wish to become pregnant. This Review provides a detailed update on the management of patients with IBD during pregnancy and breastfeeding.

    • Max N. Brondfield
    • Uma Mahadevan
    Review Article
  • In this Review, Huang et al. highlight global trends in the epidemiology of cirrhosis, including contributions of various aetiologies of liver disease, and consider what needs to be done to address projected increases in the burden of cirrhosis.

    • Daniel Q. Huang
    • Norah A. Terrault
    • Rohit Loomba
    Review Article
  • Intestinal B cell responses are crucial in maintaining gut homeostasis. This Review discusses the role of human intestinal B cells in health and intestinal disease and provides a comprehensive overview of their features.

    • Jo Spencer
    • Mats Bemark
    Review Article
  • Gasdermins (GSDMs) are proteins primarily involved in pyroptosis, among other cellular functions. This Review provides a comprehension summary of GSDM biology, focusing on the gastrointestinal tract and addressing clinical implications and future research.

    • Giuseppe Privitera
    • Nitish Rana
    • Theresa T. Pizarro
    Review Article
  • Cholangiocarcinoma is the second most common primary liver cancer, and its incidence is rising worldwide. This Review discusses the immunology of cholangiocarcinoma and provides a comprehensive overview of the preclinical and clinical immunotherapy studies.

    • Tim F. Greten
    • Robert Schwabe
    • Xin W. Wang
    Review Article
  • The therapeutic landscape of metastatic colorectal cancer (mCRC) is changing. This Review provides a comprehensive overview discussing the current mCRC advances in precision oncology and suggests a treatment strategy for mCRC with rare genomic alterations.

    • Hideaki Bando
    • Atsushi Ohtsu
    • Takayuki Yoshino
    Review Article
  • In this Review, the authors discuss gene therapy involving the use of recombinant adeno-associated virus vectors for the treatment of inherited liver diseases, including ongoing clinical trials that are producing promising results.

    • Nerea Zabaleta
    • Carmen Unzu
    • Gloria Gonzalez-Aseguinolaza
    Review Article
  • There is an increasing burden of gastrointestinal cancers in East Asia. This Review provides an updated summary of the epidemiology of gastrointestinal cancers in this region and discusses risk factors and implications for prevention.

    • Junjie Huang
    • Don Eliseo Lucero-Prisno III
    • Martin C. S. Wong
    Review Article
  • This Review discusses the current and emerging therapeutic landscape for treatment of advanced hepatocellular carcinoma, including molecular-targeted monotherapies, immuno-oncology monotherapies, combination therapies and novel therapeutic approaches.

    • Chen Yang
    • Hailin Zhang
    • Cun Wang
    Review Article
  • Primary sclerosing cholangitis (PSC) is closely associated with inflammatory bowel disease (IBD) and potentially provides unique insights into the gut–liver axis. This Review explores these links and provides an overview of the gut microbiome in PSC, including PSC–IBD, exploring related hypotheses of disease mechanisms.

    • Johannes R. Hov
    • Tom H. Karlsen
    Review Article