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The ubiquity of gluten in foodstuffs, patient compliance, and variable patient susceptibility to gluten are all limiting factors of the gluten-free diet—the treatment of choice for celiac disease. New therapeutic strategies are emerging as a result of improved understanding of the molecular events underlying celiac disease; this Viewpoint considers whether a gluten-free diet is still adequate.
Screening for colorectal cancer is effective in preventing a major cause of morbidity and mortality. Before implementing organized screening programs, however, policymakers must consider its value relative to other health-related and nonhealth-related needs. One way of doing so is cost-effectiveness analysis. This Viewpoint highlights some key issues surrounding such analysis and suggests areas for further research.