Therapeutic pipeline in nonalcoholic steatohepatitis

  • Raj Vuppalanchi
  • Mazen Noureddin
  • Arun J. Sanyal
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  • Pancreatic ductal adenocarcinoma (PDAC) reflects the current challenge for immuno-oncology: to develop new drugs for cancers that are resistant to current immunotherapies. Here, we argue for a need to use patients to uncover new strategies that activate anti-tumour immunity.

    • Luis A. Rojas
    • Vinod P. Balachandran
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  • The application of single-cell RNA sequencing platforms has generated notable insights into the heterogeneity underlying pancreatic ductal adenocarcinoma (PDAC), encompassing both the neoplastic compartment and the tumour microenvironment. In this Comment, we discuss the most pertinent findings gleaned from both mouse models and human PDAC samples, as well as future opportunities.

    • Jincheng Han
    • Ronald A. DePinho
    • Anirban Maitra
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