Nature Reviews Gastroenterology & Hepatology

The evolving landscape in HCC, inspired by the Review on p203

Evolving therapeutic landscape of advanced hepatocellular carcinoma

Chen Yang
Hailin Zhang
Cun Wang

Review Article 11 November 2022

Featured

Environmental enteric dysfunction: gut and microbiota adaptation in pregnancy and infancy

In this Review, Cowardin, Moore and colleagues discuss advances in our understanding of environmental enteric dysfunction in the context of intestinal adaptation and the gut microbiome during pregnancy, lactation and early childhood.

Carrie A. Cowardin
Sana Syed
Sean R. Moore
Review Article 16 Dec 2022
The scientific basis of combination therapy for chronic hepatitis B functional cure

In this Review, the authors consider various paths to functional cure of chronic hepatitis B (CHB) and the need to individualize therapy of this heterogeneous infection until a therapeutic avenue for all patients with CHB is available.

Seng Gee Lim
Thomas F. Baumert
Fabien Zoulim
Review Article 11 Jan 2023
Human intestinal B cells in inflammatory diseases

Intestinal B cell responses are crucial in maintaining gut homeostasis. This Review discusses the role of human intestinal B cells in health and intestinal disease and provides a comprehensive overview of their features.

Jo Spencer
Mats Bemark
Review Article 27 Feb 2023

Current issue

XVIIth Little Brain Big Brain: an extraordinary meeting in extraordinary times

Constanza Alcaino
Florencia Carbone
Naomi E. B. Tjaden
Comment 08 Feb 2023
Challenges in gastrointestinal research in Latin America

Mabel Guzman
Gisela Canedo-Marroquín
Nestor N. Jimenez-Vargas
Comment 08 Feb 2023
MAPK inhibition in BRAF^V600E CRC

Eleni Kotsiliti
Research Highlight 14 Feb 2023
Evolving therapeutic landscape of advanced hepatocellular carcinoma

Chen Yang
Hailin Zhang
Cun Wang
Review Article 11 Nov 2022
Environmental enteric dysfunction: gut and microbiota adaptation in pregnancy and infancy

Carrie A. Cowardin
Sana Syed
Sean R. Moore
Review Article 16 Dec 2022
The scientific basis of combination therapy for chronic hepatitis B functional cure

Seng Gee Lim
Thomas F. Baumert
Fabien Zoulim
Review Article 11 Jan 2023

Contents

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Announcements

2022 - Year in Review

Leading experts describe their key advances of the year. Topics covered include: IBD; IBS; pancreatic cancer; gut-brain axis; gut microbiota; NAFLD and obesity; ALD
COVID-19

FREE ACCESS - This Collection covers the COVID-19 pandemic and its implications for patients with gastrointestinal and liver diseases.
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Latest Reviews & Analysis

- Inflammatory bowel disease in pregnancy and breastfeeding
  
  The treatment landscape of inflammatory bowel disease (IBD) is constantly evolving, including among pregnant women and those who wish to become pregnant. This Review provides a detailed update on the management of patients with IBD during pregnancy and breastfeeding.
  
  Max N. Brondfield
  Uma Mahadevan
  
  Review Article 31 Mar 2023
- Global epidemiology of cirrhosis — aetiology, trends and predictions
  
  In this Review, Huang et al. highlight global trends in the epidemiology of cirrhosis, including contributions of various aetiologies of liver disease, and consider what needs to be done to address projected increases in the burden of cirrhosis.
  Daniel Q. Huang
  Norah A. Terrault
  Rohit Loomba
  
  Review Article 28 Mar 2023
- Nonalcoholic steatohepatitis-related hepatocellular carcinoma: pathogenesis and treatment
  
  In this Review, Llovet and colleagues discuss advances in our knowledge of the pathogenesis and clinical management of nonalcoholic steatohepatitis-related hepatocellular carcinoma. They also discuss future prospects and unmet needs.
  Josep M. Llovet
  Catherine E. Willoughby
  Scott L. Friedman
  
  Review Article 17 Mar 2023
- Human intestinal B cells in inflammatory diseases
  
  Intestinal B cell responses are crucial in maintaining gut homeostasis. This Review discusses the role of human intestinal B cells in health and intestinal disease and provides a comprehensive overview of their features.
  Jo Spencer
  Mats Bemark
  
  Review Article 27 Feb 2023
- The gasdermin protein family: emerging roles in gastrointestinal health and disease
  
  Gasdermins (GSDMs) are proteins primarily involved in pyroptosis, among other cellular functions. This Review provides a comprehension summary of GSDM biology, focusing on the gastrointestinal tract and addressing clinical implications and future research.
  Giuseppe Privitera
  Nitish Rana
  Theresa T. Pizarro
  
  Review Article 13 Feb 2023
- Criteria for preclinical models of cholangiocarcinoma: scientific and medical relevance
  Diego F. Calvisi
  Luke Boulter
  Yoshimasa Saito
  
  Consensus Statement 08 Feb 2023
- Immunology and immunotherapy of cholangiocarcinoma
  Tim F. Greten
  Robert Schwabe
  Xin W. Wang
  
  Review Article 25 Jan 2023
- Therapeutic landscape and future direction of metastatic colorectal cancer
  Hideaki Bando
  Atsushi Ohtsu
  Takayuki Yoshino
  
  Review Article 20 Jan 2023
- Gene therapy for liver diseases — progress and challenges
  Nerea Zabaleta
  Carmen Unzu
  Gloria Gonzalez-Aseguinolaza
  
  Review Article 16 Jan 2023

News & Comment

GLP1R agonists in NAFLD: a promising therapy on the horizon

Rula Bany Bakar
Journal Club 28 Mar 2023
Microbiota-derived metabolites in PDAC

Eleni Kotsiliti
Research Highlight 13 Mar 2023
New target and timing in PDAC immunotherapy?

Ian Fyfe
In Brief 07 Mar 2023
Safer pioglitazone alternative is effective

Ian Fyfe
In Brief 07 Mar 2023
Two therapeutic antibodies better than one

Ian Fyfe
In Brief 07 Mar 2023
Insight into virome development

Ian Fyfe
In Brief 07 Mar 2023

Viral hepatitis is a global public health problem, and the burden of disease is increasing. In 2016, spurred by development of effective new treatments for hepatitis C and expanding access to hepatitis B vaccination, the 194 Member States of the WHO committed to eliminating viral hepatitis as a public health threat by 2030. Here, Nature Reviews Gastroenterology & Hepatology explores areas vital to meeting this ambitious target, from basic viral research to public policy.

Series 16 Jun 2022