The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on fermented foods

  • Maria L. Marco
  • Mary Ellen Sanders
  • Robert Hutkins
Consensus Statement


    • The prevalence of nonalcoholic fatty liver disease (NAFLD) has increased rapidly and is associated with obesity in epidemiology and pathogenesis. A new study reports that hepatic and extrahepatic complications can develop in lean individuals with NAFLD, highlighting the importance of metabolic phenotypes in NAFLD assessment instead of BMI-based approaches.

      • Tian-Yi Ren
      • Jian-Gao Fan
      News & Views
    • Necrotizing enterocolitis (NEC) is an acute intestinal emergency in preterm infants, which is often later complicated by cognitive delay and neurodevelopmental disability. A new study performed in mice suggests that CD4+ T cells can travel from the NEC-inflamed gut to the brain and cause IFNγ-mediated brain injury.

      • Jörn-Hendrik Weitkamp
      News & Views
    • Oesophageal cancer is a global health problem with two main histological subtypes, oesophageal adenocarcinoma and oesophageal squamous cell carcinoma. This Review establishes the current epidemiology of oesophageal cancer, with a particular focus on the increasing incidence of oesophageal adenocarcinoma and its precursor, Barrett oesophagus.

      • Aaron P. Thrift
      Review Article
    • Although COVID-19 is a respiratory disease and its causative agent, SARS-CoV-2, principally infects the respiratory tract, extrapulmonary manifestations are observed. This Perspective explores the gastrointestinal symptoms associated with COVID-19 and the putative underlying mechanisms, discussing experimental evidence on SARS-COV-2 gastrointestinal infection and the potential for faecal–oral transmission.

      • Meng Guo
      • Wanyin Tao
      • Shu Zhu
    • Liver sinusoidal endothelial cells (LSECs) form the wall of the hepatic sinusoids and have essential roles in hepatic homeostasis. This Review describes the phenotypic dysregulations of LSECs in the context of liver disease and hepatocellular carcinoma, and provides an update of the role of LSECs as therapeutic targets.

      • Jordi Gracia-Sancho
      • Esther Caparrós
      • Rubén Francés
      Review Article

Nature Careers