Nature Reviews Gastroenterology & Hepatology

Robotic surgery, inspired by the Perspective on p171

Artificial intelligence and automation in endoscopy and surgery

François Chadebecq
Laurence B. Lovat
Danail Stoyanov

Perspective 09 November 2022

Featured

The microbiota and the gut–liver axis in primary sclerosing cholangitis

Primary sclerosing cholangitis (PSC) is closely associated with inflammatory bowel disease (IBD) and potentially provides unique insights into the gut–liver axis. This Review explores these links and provides an overview of the gut microbiome in PSC, including PSC–IBD, exploring related hypotheses of disease mechanisms.

Johannes R. Hov
Tom H. Karlsen
Review Article 09 Nov 2022
Current developments in gastric cancer: from molecular profiling to treatment strategy

Gastric and gastro-oesophageal cancer is a leading cause of cancer-related death worldwide with a poor prognosis. This Review provides a comprehensive overview of current treatment strategies set on a molecular basis, and discusses future therapeutic avenues.

Maria Alsina
Virginia Arrazubi
Josep Tabernero
Review Article 07 Nov 2022
Intestinal gluconeogenesis: metabolic benefits make sense in the light of evolution

Intestinal gluconeogenesis (IGN) is a conserved mechanism documented in all vertebrates and it has a crucial role in energy homeostasis and metabolic processes. This Perspective provides an overview of IGN and discusses its importance in natural selection.

Amandine Gautier-Stein
Gilles Mithieux
Perspective 05 Dec 2022

Current issue

Risk minimization of JAK inhibitors in ulcerative colitis following regulatory guidance

Silvio Danese
Virginia Solitano
Laurent Peyrin-Biroulet
Comment 19 Dec 2022
Lactylation and HCC progression

Eleni Kotsiliti
Research Highlight 07 Feb 2023
Effect of bariatric surgery on risk of oesophagogastric cancer

Jordan Hindson
In Brief 08 Feb 2023
The microbiota and the gut–liver axis in primary sclerosing cholangitis

Johannes R. Hov
Tom H. Karlsen
Review Article 09 Nov 2022
Current developments in gastric cancer: from molecular profiling to treatment strategy

Maria Alsina
Virginia Arrazubi
Josep Tabernero
Review Article 07 Nov 2022
Artificial intelligence and automation in endoscopy and surgery

François Chadebecq
Laurence B. Lovat
Danail Stoyanov
Perspective 09 Nov 2022

Contents

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Announcements

2022 - Year in Review

Leading experts describe their key advances of the year. Topics covered include: IBD; IBS; pancreatic cancer; gut-brain axis; gut microbiota; NAFLD and obesity; ALD
COVID-19

FREE ACCESS - This Collection covers the COVID-19 pandemic and its implications for patients with gastrointestinal and liver diseases.
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Latest Reviews & Analysis

- Nonalcoholic steatohepatitis-related hepatocellular carcinoma: pathogenesis and treatment
  
  In this Review, Llovet and colleagues discuss advances in our knowledge of the pathogenesis and clinical management of nonalcoholic steatohepatitis-related hepatocellular carcinoma. They also discuss future prospects and unmet needs.
  
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  Review Article 17 Mar 2023
- Human intestinal B cells in inflammatory diseases
  
  Intestinal B cell responses are crucial in maintaining gut homeostasis. This Review discusses the role of human intestinal B cells in health and intestinal disease and provides a comprehensive overview of their features.
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  Review Article 27 Feb 2023
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  Preclinical research is required to improve our understanding of cholangiocarcinoma (CCA). In this Consensus Statement, a task force of experts provides recommendations on the criteria for preclinical models of CCA to increase disease understanding and help to develop novel therapeutic approaches.
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  Review Article 25 Jan 2023
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- Improving IBD outcomes in the era of many treatment options
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  Year in Review 12 Jan 2023
- Updated epidemiology of gastrointestinal cancers in East Asia
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News & Comment

Microbiota-derived metabolites in PDAC

Eleni Kotsiliti
Research Highlight 13 Mar 2023
New target and timing in PDAC immunotherapy?

Ian Fyfe
In Brief 07 Mar 2023
Safer pioglitazone alternative is effective

Ian Fyfe
In Brief 07 Mar 2023
Two therapeutic antibodies better than one

Ian Fyfe
In Brief 07 Mar 2023
Insight into virome development

Ian Fyfe
In Brief 07 Mar 2023
Mucus secretion from colonic goblet cells is regulated by autophagy and ER stress

Jordan Hindson
Research Highlight 01 Mar 2023

In this article series, Nature Reviews Gastroenterology & Hepatology examines the cutting-edge techniques and technologies currently applied in gastrointestinal and liver research and clinical practice, and the approaches that might be available to investigators, clinicians and surgeons in the future.

Series 07 Jan 2022