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Inflammasomes in the gastrointestinal tract: infection, cancer and gut microbiota homeostasis

Latest Reviews

  • Nat Rev Gastroentero | Review Article |

    The liver is a key metabolic organ, and alterations to hepatic metabolism are important for the development of disease. In this Review, the authors explore the central roles of peroxisome proliferator-activated receptor-γ coactivators (PGC1s) in physiological and pathophysiological settings, with a focus on nonalcoholic fatty liver disease and liver cancer.

    • Elena Piccinin
    • , Gaetano Villani
    •  & Antonio Moschetta
  • Nat Rev Gastroentero | Review Article |

    In this Review, Yadav and Petrov discuss the most up-to-date epidemiological data on acute and chronic pancreatitis. The authors also present strategies to reduce the burden of pancreatitis and its associated metabolic disorders.

    • Maxim S. Petrov
    •  & Dhiraj Yadav
  • Nat Rev Gastroentero | Review Article |

    The pathophysiology of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis is not yet completely understood but innate immunity is a major factor. In this Review, the evidence for macrophage involvement in the development of liver steatosis, inflammation and fibrosis is discussed.

    • Konstantin Kazankov
    • , Simon Mark Dahl Jørgensen
    • , Karen Louise Thomsen
    • , Holger Jon Møller
    • , Hendrik Vilstrup
    • , Jacob George
    • , Detlef Schuppan
    •  & Henning Grønbæk
  • Nat Rev Gastroentero | Review Article |

    This Review outlines the current understanding of IL-12 and IL-23 biology in IBD, as well as the roles of major downstream cytokines, including IL-17. The authors also discuss how emerging knowledge influences the development of therapeutic strategies in IBD.

    • Alexander R. Moschen
    • , Herbert Tilg
    •  & Tim Raine
  • Nat Rev Gastroentero | Review Article |

    The Wnt–β-catenin pathway is a highly conserved pathway that regulates embryogenesis and key regenerative processes in adult organs. Here, the authors discuss the role of Wnt–β-catenin signalling in liver development and disease, including in liver cancer, NAFLD and liver fibrosis.

    • Maria J. Perugorria
    • , Paula Olaizola
    • , Ibone Labiano
    • , Aitor Esparza-Baquer
    • , Marco Marzioni
    • , Jose J. G. Marin
    • , Luis Bujanda
    •  & Jesus M. Banales
  • Nat Rev Gastroentero | Review Article |

    Redox signalling in the gastrointestinal mucosa is held in an intricate balance. This Review addresses both the spectrum and intensity of redox activity pertaining to host–immune and host–microbiota crosstalk during homeostasis and disease processes in the gastrointestinal tract.

    • Eric L. Campbell
    •  & Sean P. Colgan

News & Comment

Focus

Gastrointestinal cancer and obesity

Laura Marshall

Gastrointestinal cancer and obesity

This Collection brings together articles published in our Focus issue on gastrointestinal cancer and obesity. Featuring specially commissioned Reviews and Comments, these articles discuss the advances made in our understanding of how obesity affects the risk of gastrointestinal cancer.

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