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Volume 24 Issue 2, February 2023

Inspired by the Review on p73

Cover design: Patrick Morgan

Research Highlights

  • A study in Nature reports the identification of new germline variants associated with particular subtypes of clonal haematopoiesis of indeterminate potential (CHIP) and their links to different health outcomes.

    • Kirsty Minton
    Research Highlight

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  • A comparative genomics study published in Nature Communications provides new insight into the genomic changes underlying the convergent evolution of sociality in spiders.

    • Dorothy Clyde
    Research Highlight
  • A new study in Nature Methods describes a computational method named UTAG (unsupervised discovery of tissue architecture with graphs) that aims to identify and quantify higher-level tissue domains from biological images without previous knowledge.

    • Linda Koch
    Research Highlight
  • Two new studies in Science characterize a CRISPR-associated nuclease–protease system that can be leveraged as a programmable protease-based RNA sensor.

    • Darren J. Burgess
    Research Highlight
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Reviews

  • Inducible protein degradation technologies enable the depletion of loop extrusion factors within short time frames, leading to the rapid reconfiguration of the 3D genome. Nora and de Wit review insights from degron approaches into the molecular factors controlling genome folding and how these findings have changed our understanding of genome organization, including its role in transcription.

    • Elzo de Wit
    • Elphège P. Nora
    Review Article
  • Mendelian defects in genes encoding factors that regulate telomere length, structure and function cause telomeropathies, or telomere biology disorders (TBDs). The authors review confirmed as well as potential TBD-causing genes and their main functions in telomere biology. They also discuss genetic features that underlie the complex nature of these diseases.

    • Patrick Revy
    • Caroline Kannengiesser
    • Alison A. Bertuch
    Review Article
  • Microbiome epidemiology associates microbial community features with health outcomes, traits or exposures in human host populations. In this Review, the authors discuss ways in which various microbiome features at varying levels of resolution (community, strain, pathway or gene) influence human health using established examples of microbiome-associated changes linked with host outcomes.

    • Hannah VanEvery
    • Eric A. Franzosa
    • Curtis Huttenhower
    Review Article
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