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Volume 23 Issue 5, May 2022

Inspired by the Review on p265.

Cover design: Patrick Morgan.

Research Highlights

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  • Michael Purugganan reflects on a 100-year-old publication by Nikolai Vavilov, which postulated a new law of genetics from which key evolutionary insights emerged and which guided future molecular genetic investigations.

    • Michael D. Purugganan
    Journal Club
  • A recent paper in Nature describes how CRISPR-based engineering of wheat confers robust resistance to powdery mildew disease without negatively impacting crop growth and yields.

    • Xian Deng
    • Xiaofeng Cao
    Research Highlight
  • Omary et al. map shoot-borne root development at single-cell resolution in tomato to identify the origin of shoot-borne roots.

    • Linda Koch
    In Brief
  • A recent study in Nature Genetics investigates the role of DNA replication in cellular plasticity during mouse embryonic development.

    • Linda Koch
    In Brief
  • A paper in Science describes a system in synthetic yeast chromosomes in which the properties of genetic sequences change depending on the neighbouring transcriptional activity.

    • Lucia Brunello
    Research Highlight
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  • RNA therapies can be used to manipulate gene expression or produce therapeutic proteins. Here, the authors describe the growing number of RNA therapies and their molecular mechanisms of action. They also discuss the path from preclinical drug delivery research to clinical approval of these drugs.

    • Kalina Paunovska
    • David Loughrey
    • James E. Dahlman
    Review Article
  • Hologenomic studies aim to further our understanding of host–microbiota interactions through the integrated analysis of host genomes and microbiota metagenomes. Here, Alberdi and colleagues discuss key considerations for designing optimal hologenomic studies and outline important biological questions that these studies can address.

    • Antton Alberdi
    • Sandra B. Andersen
    • M. Thomas P. Gilbert


    Review Article
  • In this Review the authors provide an overview of key algorithmic developments, popular tools and emerging technologies used in the bioinformatic analysis of genomes. They also describe how such analysis can identify point mutations, copy number alterations, structural variations and mutational signatures in cancer genomes.

    • Isidro Cortés-Ciriano
    • Doga C. Gulhan
    • Peter J. Park
    Review Article
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Expert Recommendation

  • Cell fusion models containing genomes from different cell types or species in a single nucleus offer unique research benefits. Here, Pavlovic et al. advocate against describing such models as hybrids and propose a new nomenclature for interspecies cell fusions that lacks reproductive connotations.

    • Bryan J. Pavlovic
    • Dov Fox
    • Alex A. Pollen
    Expert Recommendation
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