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Volume 22 Issue 12, December 2021

Inspired by the Review on p757.

Cover design: Patrick Morgan.

Volume 22 Issue 12

Research Highlights

  • Two recent studies demonstrate that putative nucleases encoded by IS200/IS605 family transposons are programmable RNA-guided DNA endonucleases, which could represent a new source of genome-editing enzymes for biotechnological applications.

    • Grant Otto
    Research Highlight


  • A study in Nature describes single-cell ribosome sequencing, which advances single-cell genomics by enabling the measurement of translational dynamics in single cells.

    • Katharine H. Wrighton
    Research Highlight
  • A study in Nature Biotechnology describes single-cell genome and epigenome by transposases sequencing (scGET-seq), which generates euchromatin and heterochromatin profiles from the same cell, and Chromatin Velocity, a computational framework capable of predicting future epigenetic cell fate trajectories from scGET-seq data.

    • Dorothy Clyde
    Research Highlight
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  • In this Viewpoint, five experts discuss our biological understanding of super-enhancers, how we can responsibly study their functions, and their opinions on whether names for enhancer clusters are an informative reflection of their functional properties.

    • Gerd A. Blobel
    • Douglas R. Higgs
    • Richard A. Young
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  • In this Review, the authors describe our latest understanding of the emergence and properties of SARS-CoV-2 genetic variants, particularly those designated as WHO (World Health Organization) ‘variants of concern’. They focus on the consequences of these variants for antibody-mediated virus neutralization, with important implications for reinfection risk and for vaccine effectiveness.

    • Kaiming Tao
    • Philip L. Tzou
    • Robert W. Shafer


    Review Article
  • In this Review, the authors discuss computational methods for interpreting the molecular and clinical effects of genetic variants. They focus on methods leveraging machine learning, including those that characterize the effects on wider molecular networks.

    • Aaron K. Wong
    • Rachel S. G. Sealfon
    • Olga G. Troyanskaya
    Review Article
  • Leigh and colleagues describe the potential of the emerging field of macrogenetics to improve conservation and biodiversity management. Challenges preventing the field from reaching its full promise are highlighted and possible solutions and a framework for future macrogenetic studies are proposed.

    • Deborah M. Leigh
    • Charles B. van Rees
    • Ivan Paz-Vinas
    Review Article
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Amendments & Corrections

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