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A study in Science describes the generation of a lineage-resolved single-cell transcriptome atlas for Caenorhabditis elegans embryos. This resource provides insight into the transcriptional changes underlying cell fate decisions.
This Review discusses advances in RNA-sequencing technologies and methods over the past decade and outlines adaptations that are enabling a fuller understanding of RNA biology, from when and where an RNA is expressed to the structures it adopts.
The cGAS–STING pathway forms a major DNA-sensing mechanism in mammalian cells. This Review summarizes the current knowledge of cGAS–STING signalling and regulation, highlighting emerging evidence of its role in monogenic inflammatory diseases and cancer and new therapeutic opportunities.
In eukaryotes, circular RNAs (circRNAs) carry out important biological roles by acting as microRNA or protein sponges, regulating protein function or through cap-independent translation. New technologies for identifying and characterizing circRNAs will increase our knowledge of their biogenesis and function in health and disease.
In a recent declaration, 21 European countries committed to sharing data on at least 1 million human genomes by 2022. This Roadmap emphasizes the challenges of genomic data sharing across borders and how European research infrastructures can support the rapid implementation of transnational access to genomic data.