Volume 20 Issue 11, November 2019

Volume 20 Issue 11

Inspired by the Review on p631

Cover design: Patrick Morgan

Research Highlights

  • Research Highlight |

    Two new studies in Science survey diversity in malarial Plasmodium species, assessing genetic diversity across Africa, as well as transcriptomic diversity through the pathogen life cycle.

    • Darren J. Burgess
  • Research Highlight |

    A recent study in Nature Microbiology reports metagenomic signatures of early-life antibiotic treatment and hospitalization associated with preterm birth that persist long-term.

    • Linda Koch
  • Research Highlight |

    A study in Science describes the generation of a lineage-resolved single-cell transcriptome atlas for Caenorhabditis elegans embryos. This resource provides insight into the transcriptional changes underlying cell fate decisions.

    • Dorothy Clyde

Reviews

  • Review Article |

    This Review discusses advances in RNA-sequencing technologies and methods over the past decade and outlines adaptations that are enabling a fuller understanding of RNA biology, from when and where an RNA is expressed to the structures it adopts.

    • Rory Stark
    • , Marta Grzelak
    •  & James Hadfield
  • Review Article |

    The cGAS–STING pathway forms a major DNA-sensing mechanism in mammalian cells. This Review summarizes the current knowledge of cGAS–STING signalling and regulation, highlighting emerging evidence of its role in monogenic inflammatory diseases and cancer and new therapeutic opportunities.

    • Mona Motwani
    • , Scott Pesiridis
    •  & Katherine A. Fitzgerald
  • Review Article |

    In eukaryotes, circular RNAs (circRNAs) carry out important biological roles by acting as microRNA or protein sponges, regulating protein function or through cap-independent translation. New technologies for identifying and characterizing circRNAs will increase our knowledge of their biogenesis and function in health and disease.

    • Lasse S. Kristensen
    • , Maria S. Andersen
    • , Lotte V. W. Stagsted
    • , Karoline K. Ebbesen
    • , Thomas B. Hansen
    •  & Jørgen Kjems

Roadmap

  • Roadmap |

    In a recent declaration, 21 European countries committed to sharing data on at least 1 million human genomes by 2022. This Roadmap emphasizes the challenges of genomic data sharing across borders and how European research infrastructures can support the rapid implementation of transnational access to genomic data.

    • Gary Saunders
    • , Michael Baudis
    • , Regina Becker
    • , Sergi Beltran
    • , Christophe Béroud
    • , Ewan Birney
    • , Cath Brooksbank
    • , Søren Brunak
    • , Marc Van den Bulcke
    • , Rachel Drysdale
    • , Salvador Capella-Gutierrez
    • , Paul Flicek
    • , Francesco Florindi
    • , Peter Goodhand
    • , Ivo Gut
    • , Jaap Heringa
    • , Petr Holub
    • , Jef Hooyberghs
    • , Nick Juty
    • , Thomas M. Keane
    • , Jan O. Korbel
    • , Ilkka Lappalainen
    • , Brane Leskosek
    • , Gert Matthijs
    • , Michaela Th. Mayrhofer
    • , Andres Metspalu
    • , Arcadi Navarro
    • , Steven Newhouse
    • , Tommi Nyrönen
    • , Angela Page
    • , Bengt Persson
    • , Aarno Palotie
    • , Helen Parkinson
    • , Jordi Rambla
    • , David Salgado
    • , Erik Steinfelder
    • , Morris A. Swertz
    • , Alfonso Valencia
    • , Susheel Varma
    • , Niklas Blomberg
    •  & Serena Scollen

Amendments & Corrections

  • Author Correction |

    • Gary Saunders
    • , Michael Baudis
    • , Regina Becker
    • , Sergi Beltran
    • , Christophe Béroud
    • , Ewan Birney
    • , Cath Brooksbank
    • , Søren Brunak
    • , Marc Van den Bulcke
    • , Rachel Drysdale
    • , Salvador Capella-Gutierrez
    • , Paul Flicek
    • , Francesco Florindi
    • , Peter Goodhand
    • , Ivo Gut
    • , Jaap Heringa
    • , Petr Holub
    • , Jef Hooyberghs
    • , Nick Juty
    • , Thomas M. Keane
    • , Jan O. Korbel
    • , Ilkka Lappalainen
    • , Brane Leskosek
    • , Gert Matthijs
    • , Michaela Th. Mayrhofer
    • , Andres Metspalu
    • , Arcadi Navarro
    • , Steven Newhouse
    • , Tommi Nyrönen
    • , Angela Page
    • , Bengt Persson
    • , Aarno Palotie
    • , Helen Parkinson
    • , Jordi Rambla
    • , David Salgado
    • , Erik Steinfelder
    • , Morris A. Swertz
    • , Alfonso Valencia
    • , Susheel Varma
    • , Niklas Blomberg
    •  & Serena Scollen