Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
Two recent studies report innovative RNA base editing tools: adenine editing without the requirement for exogenous enzymes, and a new ability to edit cytosines.
A study in Nature Ecology and Evolution reports the genome sequence of the Komodo dragon and describes genomic features that may underlie its distinct physiology.
A study in Nature Genetics shows that genomic rearrangements that cause extensive changes to chromatin topology do not alter expression for the majority of genes.
In this Review, van Rheenen et al. outline how improved methodologies have enabled genetic correlations to be estimated for almost any trait pair. Genetic correlations can improve our understanding of the shared biology and causal relationships between traits.
Somatic genetic rescue (SGR) occurs when an acquired somatic mutation counteracts the effects of a germline mutation at a cellular level. The increasing number of SGR events reported for Mendelian haematopoietic diseases have important diagnostic, therapeutic and clinical consequences.
In most human genes, RNA 3ʹ end cleavage and polyadenylation can occur at multiple, alternative sites, enabling the expression of distinct transcripts. Novel techniques to sequence RNA 3ʹ ends, coupled with innovative computational methods for studying the list of polyadenylation sites that they generate, have uncovered the roles of alternative cleavage and polyadenylation in both health and disease.
Earth’s landscapes and biodiversity are being eroded at an unprecedented pace and scale. This Review argues that genomics tools need to be adopted in restoration ecology to help reverse the environmental destruction caused by humans.
